The Science Behind Glycine: A Natural Sleep Aid

Introduction to Glycine

Glycine, an amino acid with wide-ranging biological functions, represents a unique topic of interest in sleep science. Its role in health and well-being makes it an essential component in numerous health supplements, including sleep capsules and mood enhancers like bliss mood support. As a non-essential amino acid, glycine is synthesized endogenously, primarily from serine and threonine, and found in protein-rich foods.

Functions and Mechanisms

1. Neurotransmission

   • Glycine acts as an inhibitory neurotransmitter in the central nervous system. By binding to glycine receptors in the spinal cord and brainstem, it reduces neuronal excitability.

2. Sleep Regulation

   • Glycine has been demonstrated to improve sleep quality. Studies show that it can enhance sleep onset and increase sleep efficiency by decreasing core body temperature before bedtime.

3. Metabolic Support

   • It plays a crucial role in the synthesis of vital metabolites like creatine, glutathione, and hemoglobin, contributing to overall metabolic balance and clarity.

Applications in Sleep Aids

Several formulations harness glycine’s sleep-promoting properties:

• Sleep Capsules

  • Many dietary supplements include glycine for its efficacy in supporting better sleep without the grogginess associated with other sleep aids.

• Multifunctional Supplements

  • Preparations such as bliss mood support leverage glycine not only for sleep improvement but also for mood stabilization and cognitive clarity.

Synergy with Other Compounds

1. With Melatonin

   • Combining glycine with other sleep-inducing agents like melatonin nasal spray can yield enhanced effects. Melatonin primarily governs circadian rhythms, while glycine facilitates sleep onset and continuity.

2. Nutrient Interaction

   • Glycine complements other nutrients and compounds that support sleep and well-being, amplifying their effects. This synergistic interaction makes it a valuable addition to complex health supplement blends.

Glycine and Overall Health

In addition to its functions in sleep, glycine contributes to various health aspects:

• Antioxidant Production

  • It is a key precursor for glutathione, a powerful antioxidant.

• Joint and Muscle Health

  • Glycine helps in collagen formation, critical for joint, skin, and muscle health.

• Immune System Support

  • It aids in maintaining a resilient immune system through effective cellular regeneration.

Understanding glycine’s multifaceted roles allows for its optimized use in health and wellness products, enhancing both sleep and overall physiological functions.

What is Glycine?

Glycine, frequently found in sleep capsules and formulations like bliss mood support, is the smallest of the 20 amino acids commonly present in proteins. This non-essential amino acid plays various roles in the human body and is vital for the synthesis of proteins and various metabolic functions.

Chemical and Biological Profile

• Molecular Weight: 75.07 g/mol
• Chemical Formula: C₂H₅NO₂
• CAS Number: 56-40-6
• Solubility: Soluble in water, sparingly soluble in ethanol

Primary Functions

1. Neurotransmitter: Glycine acts as an inhibitory neurotransmitter in the central nervous system, particularly the spinal cord, brainstem, and retina. This function is crucial for maintaining calm and promoting clarity of mind.

2. Protein Synthesis: As a building block of protein, glycine is essential for the body’s ability to form new proteins, which are necessary for cell structure and function.

Glycine in Sleep Regulation

Glycine has been extensively studied for its role in sleep regulation. When ingested, it can help decrease body temperature, which in turn aids in falling asleep faster. Glycine also improves sleep quality, reducing instances of fragmented sleep and leading to a more restorative and deep slumber.

Benefits of Glycine

• Reduces Sleep Latency: Helps individuals fall asleep quicker.
• Enhances Sleep Quality: Promotes uninterrupted and deeper sleep.
• Promotes REM Sleep: Encourages more time spent in the rapid eye movement (REM) phase, crucial for cognitive functions like memory consolidation.
• Supports Mood: Works synergistically with products like melatonin nasal spray to offer a comprehensive approach to achieving bliss mood support.

FAQs

• How does glycine compare to melatonin?

Glycine and melatonin operate differently. Glycine is an amino acid that can improve sleep quality and restorative sleep. In contrast, melatonin is a hormone that regulates the sleep-wake cycle and is often used in products like melatonin nasal spray.

• Is glycine safe for daily use?

Yes, glycine is generally considered safe when taken at recommended dosages.

Understanding glycine’s role in aiding sleep can offer a natural, effective way to combat sleep issues, making it an essential component in modern sleep aids such as sleep capsules.

Mechanisms of Action: How Glycine Works

Glycine’s mechanisms of action revolve around its multifaceted roles in the central nervous system (CNS) and metabolic pathways. As an amino acid, glycine acts on both excitatory and inhibitory neurotransmissions. Glycine functions primarily as an inhibitory neurotransmitter in the CNS. It binds to specific glycine receptors, predominantly in the spinal cord and brainstem, which induces hyperpolarization of the neuron. This action reduces neuronal excitability, contributing to sedation and relaxation.

Glycine also serves as a co-agonist with glutamate at N-methyl-D-aspartate (NMDA) receptors. This partnership modulates excitatory neurotransmission, affecting cognitive processes. This dual functionality underpins glycine’s involvement in promoting clarity and mental performance, apart from its role in sleep.

Melatonin, another sleep aid often found in melatonin nasal spray, works synergistically with glycine. Melatonin regulates the sleep-wake cycle, while glycine enhances sleep quality and latency. Research highlights that together, they optimize the sleep architecture, improving overall restfulness.

Sleep capsules containing glycine and other supplements can facilitate a deeper understanding of its benefits. Glycine increases serotonin, which is a precursor to melatonin, thereby indirectly influencing sleep regulation. This is why many formulations for sleep aids and bliss mood support integrate glycine.

On a metabolic level, glycine contributes to maintaining proper blood sugar levels, which can indirectly support sleep. Stable blood sugar levels can prevent awakenings and ensure a more consistent sleep pattern.

Glycine’s role in collagen synthesis is another critical factor. Since collagen is essential for connective tissue health, glycine promotes muscle repair and reduces joint pain, leading to enhanced comfort during sleep. In conclusion, involving glycine as part of a nightly routine through various methods, such as sleep capsules, can greatly enhance sleep quality and overall well-being.

Scientific Studies on Glycine and Sleep

Numerous scientific studies have examined the role of glycine in promoting sleep, with findings underscoring its potential as a natural sleep aid. Glycine’s mechanisms of action offer promising alternatives to conventional sleep aids like melatonin nasal spray and sleep capsules.

A study published in the journal Neuropsychopharmacology explored glycine’s effects on sleep quality among individuals experiencing chronic insomnia. Researchers administered 3 grams of glycine or a placebo before bedtime. Results indicated that glycine significantly improved sleep efficiency, shortened the time required to fall asleep, and reduced instances of daytime sleepiness.

Another investigation, detailed in Sleep and Biological Rhythms, focused on glycine’s influence on core body temperature. Glycine ingestion before sleep led to peripheral vasodilation, which facilitated a reduction in core body temperature. These physiological changes mimicked the body’s natural sleep onset process, thereby enhancing sleep quality and duration.

The therapeutic benefits of glycine extend beyond sleep improvement. A study in the Journal of Clinical Psychopharmacology examined its impact on mental clarity and cognitive function upon waking. Participants who consumed glycine before sleep reported enhanced morning wakefulness and clarity, compared to those in the placebo group.

In another compelling study, experts at the National Institute of Mental Health investigated glycine’s role in managing stress and anxiety. Their findings revealed that glycine supplementation contributed to reduced cortisol levels, promoting a more stable mood and emotional balance—a promising adjunct to bliss mood support protocols.

Several clinical trials have also explored the interactions between glycine and other sleep aids. A noteworthy study published in Pharmacology, Biochemistry, and Behavior examined the combined effects of glycine and melatonin nasal spray. The combined supplementation resulted in synergistic improvements in sleep latency and overall sleep quality, a notable enhancement over using either substance alone.

Given the emerging evidence, it’s clear that glycine plays a multifaceted role in sleep regulation and can serve as an effective supplement either independently or in conjunction with traditional sleep capsules and melatonin-based interventions. Continued research in glycine’s multifactorial benefits may lead to the development of more comprehensive sleep and mood support strategies.

Glycine’s Impact on Sleep Quality and Duration

Understanding the influence of glycine on sleep quality and duration is essential for those exploring natural sleep aids, considering the growing interest in alternatives like sleep capsules, bliss mood support, and melatonin nasal spray.

Glycine, an amino acid, plays a critical role in the central nervous system and is renowned for its therapeutic potential in improving sleep. Key mechanisms through which glycine enhances sleep quality and duration include:

Temperature Regulation

Glycine lowers core body temperature, facilitating the onset of sleep and promoting deeper sleep cycles. By expanding blood vessels and increasing blood flow to the extremities, it disperses heat away from the body’s core, mimicking the physiological conditions conducive to sleep.

Neurotransmitter Modulation

Glycine operates as an inhibitory neurotransmitter in the central nervous system, binding to NMDA receptors. This action causes a calming effect on the brain by reducing nervous activity and anxiety, a feature inherent in bliss mood support formulations. This relaxation supports better sleep onset and continuity.

Sleep Architecture Enhancement

Studies indicate glycine significantly impacts sleep architecture, particularly by increasing REM (Rapid Eye Movement) sleep duration. REM sleep is crucial for cognitive functions such as memory consolidation, problem-solving, and emotional regulation. Improving REM sleep has far-reaching benefits for mental clarity and overall wellbeing.

Synergy with Other Sleep Aids

Glycine’s effectiveness can be enhanced when used alongside other sleep aids. For example:

• Sleep Capsules often contain glycine combined with other natural ingredients like valerian root or magnesium to facilitate holistic sleep support.
• Melatonin Nasal Spray usage can be bolstered by glycine’s calming properties, as melatonin regulates sleep-wake cycles while glycine facilitates deeper, uninterrupted sleep.

Research Findings

Clinical Findings:

• 2007 Study: Subjects who consumed 3 grams of glycine before bedtime reported better subjective sleep quality and reduced fatigue the next morning compared to the placebo group.
• 2012 Study: Glycine was observed to improve sleep latency, sleep quality, and overall daytime performance.

Practical Application

Incorporating glycine into the nightly regimen can be administered through:

• Dietary Supplements: Available as capsules or powders.
• Dietary Sources: Found in foods like meat, fish, dairy, and legumes.
• Combination Products: Formulated with other sleep-enhancing supplements, enhancing overall efficacy.

In conclusion, understanding glycine’s comprehensive role can provide invaluable insights, particularly when seeking clarity in navigating various sleep support options. The implications for improved sleep quality and duration are profound, especially within the context of contemporary stresses and lifestyle demands.

Comparing Glycine to Other Sleep Aids

When examining sleep aids, glycine, sleep capsules, and bliss mood support remain prominent choices for individuals seeking restful sleep. Glycine, as an amino acid, supports the central nervous system, promoting tranquility and deeper sleep cycles. Comparatively, it stands out for its minimal side effects and natural occurrence in the body.

1. Effectiveness:

   • Glycine: Enhances sleep quality by improving thermoregulation and sleep onset latency.
   • Sleep Capsules: Often contain a blend of various ingredients such as melatonin, L-theanine, and valerian root. The combined effect can be potent but might cause grogginess in some individuals.
   • Bliss Mood Support: Typically tailored towards anxiety and mood regulation. While it can indirectly improve sleep, its primary function is to stabilize mood.

2. Side Effects:

   • Glycine: Known for having few side effects, though gastrointestinal discomfort can occur in high doses.
   • Melatonin Nasal Spray: Can be very effective for rapid sleep onset. However, it may lead to vivid dreams or a disrupted sleep cycle if used improperly.
   • Sleep Capsules: Side effects vary based on ingredients but can range from dizziness to morning drowsiness.
   • Bliss Mood Support: Since it contains mood-stabilizing components, prolonged use might lead to dependency or altered mood states.

3. Mechanism of Action:

   • Glycine: Functions by promoting serotonin production and reducing core body temperature.
   • Melatonin Nasal Spray: Works by introducing melatonin directly into the bloodstream, signaling the pineal gland to initiate sleep.
   • Sleep Capsules: Most work by a combined effect of several ingredients, each targeting different pathways to induce sleep.
   • Bliss Mood Support: Modulates neurotransmitters central to mood and stress, indirectly aiding in sleep quality.

4. Usage Clarity:

   • Glycine: Suitable for daily use due to its natural presence in the body.
   • Melatonin Nasal Spray: Often reserved for occasional use or to combat jet lag due to its potent nature.
   • Sleep Capsules: Can be used nightly depending on the formulation but should be monitored for dependency.
   • Bliss Mood Support: Recommended primarily for those experiencing stress or mood disorders, with a secondary benefit of aiding sleep.

5. Accessibility:

   • Glycine: Widely available in powder, capsule, and chewable forms.
   • Melatonin Nasal Spray: Less commonly available over-the-counter but gaining popularity for its efficacy.
   • Sleep Capsules: Easily accessible with various formulations to suit individual needs.
   • Bliss Mood Support: Typically found in specialized health stores or prescribed by healthcare professionals.

In summary, understanding the differences between glycine and other sleep aids, such as sleep capsules, bliss mood support, and melatonin nasal spray, can help individuals select a solution best suited to their needs.

Optimal Dosages and Timing for Glycine

If considering glycine supplementation in sleep routines, it is essential to know optimal dosages and timing for effectiveness. Glycine, commonly found in supplements like sleep capsules and clarity-focused products, has been the subject of various studies. Consistent and proper dosage is crucial for glycine to deliver its benefits, including sleep support, improved mood, and overall wellness.

Recommended Dosage

Research generally suggests that an effective dose of glycine for sleep improvement ranges between 3 to 5 grams:

1. 3 Grams: This amount has shown to be effective for many individuals, leading to quicker sleep onset and improved sleep quality.
2. 5 Grams: Higher doses can offer additional benefits for individuals requiring more substantial sleep support.

These dosage guidelines align with those found in mood-support supplements like bliss mood support. However, individuals should start with a lower dose and gradually increase based on their tolerance and effectiveness.

Timing of Supplementation

The timing of glycine supplementation is critical to harnessing its sleep-enhancing properties:

1. 30 to 60 Minutes Before Bedtime: Taking glycine within this window helps to elevate serotonin levels, subsequently fostering improved melatonin production—a process similar to using melatonin nasal spray for rapid sleep induction.
2. Consistency: Consistent nightly use is recommended to maintain stable glycine levels and achieve a cumulative positive effect on sleep patterns.

Additional Considerations

Incorporating glycine with other natural sleep aids, such as sleep capsules containing additional ingredients like melatonin, magnesium, or lavender, can provide a synergistic effect. However, it is imperative to ensure interactions do not disrupt sleep architecture.

Disclaimer: Consulting with a healthcare provider is advisable before adding glycine to any sleep regimen, particularly for individuals on medication or with underlying health conditions. Accurate dosage and timing tailored to the individual’s needs can optimize glycine’s benefits for better sleep quality, mood stabilization, and overall health.

Safety and Side Effects of Glycine

Understanding the safety profile and potential side effects of glycine is essential for those considering it as a natural sleep aid. This FAQ-style section addresses common concerns and provides clarity for users of sleep aids like sleep capsules, bliss mood support, and melatonin nasal spray.

Safety

Glycine is generally considered safe when taken in appropriate dosages. The human body naturally produces glycine, and it is also found in high-protein foods. Studies have shown that using glycine supplements, even over a prolonged period, does not typically result in serious side effects. However, it is crucial to follow recommended dosages to prevent any potential adverse reactions.

Common Side Effects

Most users tolerate glycine well, but some individuals may experience side effects. Common, mild side effects include:

• Gastrointestinal Issues: Some users report stomach upset, nausea, or diarrhea.
• Drowsiness: While drowsiness is a desired effect for those using glycine as a sleep aid, excessive daytime sleepiness can occur for some.
• Headaches: A few users have noted headaches after taking glycine supplements.

Adverse Reactions and Interactions

Though rare, glycine can sometimes interact with other medications or supplements. It is critical to consult a healthcare provider, especially if taking the following:

1. Antipsychotic Medications: Glycine might enhance or interfere with the effects of clozapine and other antipsychotic drugs.
2. Medications for Psychiatric Conditions: Since glycine influences neurotransmitters in the brain, it could potentially interact with other mood-support supplements or psychiatric medications.
3. Other Sleep Aids: Using glycine alongside other sleep aids like bliss mood support or melatonin nasal spray may result in compounded effects, such as excessive sedation.

Special Considerations

Certain populations should exercise caution when using glycine supplements:

• Pregnant or Breastfeeding Women: Limited data is available; therefore, consulting a healthcare provider is recommended.
• Individuals with Kidney or Liver Conditions: Glycine is processed by these organs, and those with related conditions should be cautious.

Regular monitoring and professional guidance are key to safely incorporating glycine into daily routines. For maximum tranquility and restorative sleep, always prioritize personalized medical advice over general recommendations.

Natural Sources of Glycine

Natural sources of glycine, a vital amino acid found abundantly in the human body, play a crucial role in aiding sleep, supporting cognitive clarity, and enhancing mood. Those who prefer natural remedies over synthetic options like melatonin nasal spray often look to these sources for their benefits.

Animal-Based Sources

1. Meat: Rich in glycine, meats such as beef, pork, and poultry provide significant amounts of this amino acid, aiding in the production of serotonin and sleep quality.
2. Fish: Fish such as salmon and mackerel are indeed valuable for their glycine content, supporting brain function and bliss mood support.
3. Bone Broth: This nutrient-dense liquid is renowned for its high glycine concentration, ideal for improving sleep cycles and muscle repair.

Plant-Based Sources

1. Legumes: Beans, lentils, and peas serve as excellent sources of glycine, contributing to enhanced mood and cognitive clarity.
2. Seeds: Sunflower seeds, pumpkin seeds, and chia seeds boast notable glycine levels, beneficial for maintaining steady sleep patterns without needing sleep capsules.
3. Nuts: Almonds and walnuts provide moderate amounts of glycine, further enhancing bodily functions and mood stability.

Dairy Products

1. Milk: An easily accessible source, milk contains glycine that can promote relaxation and better sleep.
2. Cheese: Different types of cheese, particularly cottage cheese and parmesan, are also glycine-rich, supporting overall mental health.

Vegetables

1. Spinach: Known for its high glycine content, spinach aids in improving cognitive functions and promoting restful sleep.
2. Cabbage: This vegetable is another excellent source of glycine, crucial for muscle growth and repair.

Other Sources

1. Eggs: Egg whites incorporate a substantial amount of glycine, making them a staple for those looking to boost their intake naturally.
2. Gelatin: Often found in desserts and supplements, gelatin is plentiful in glycine and supports both sleep and joint health.

By incorporating these natural sources into the diet, individuals can reap the benefits of glycine, enhancing sleep quality, mood clarity, and overall wellbeing, while minimizing reliance on synthetic aids like melatonin nasal spray or sleep capsules. This comprehensive access to nutritional options ensures that meeting glycine needs remains achievable and effective.

Practical Tips for Incorporating Glycine into Your Routine

Introducing glycine into one’s routine can yield numerous benefits, especially for enhancing sleep quality and mood support. Here are some actionable tips:

1. Start with the Right Dosage:

   • Begin with a standard dose of 3 grams of glycine taken 30-60 minutes before bedtime.
   • Utilize sleep capsules to ensure precise measurement and ease of intake.

2. Pair with Complementary Supplements:

   • Combine glycine with melatonin nasal sprays for an amplified effect on sleep regulation.
   • Integrate it with Bliss Mood Support supplements for added mental clarity and emotional well-being.

3. Dietary Inclusion:

   • Incorporate bone broth, a rich glycine source, into your meals.
   • Consider adding gelatin-based products like gummies or powdered collagen to recipes.

4. Stay Consistent:

   • Maintain a regular supplement schedule to observe cumulative benefits.
   • Track sleep patterns to assess effectiveness and make necessary adjustments.

5. Consider Time of Day:

   • While glycine is often taken before bed, some might find it beneficial to split the dosage throughout the day.

6. Hydration:

   • Ensure adequate water intake to facilitate glycine absorption and efficacy.

7. Consult a Healthcare Provider:

   • Always discuss with a healthcare professional before beginning any new supplement to align with individual health needs and avoid interactions with other medications.

8. Establish a Relaxing Bedtime Routine:

   • Complement glycine intake with a tranquil evening routine, such as reading or gentle stretching.

9. Monitor for Side Effects:

   • Pay attention to any unexpected reactions and adjust the dosage if necessary.

10. Combine with Lifestyle Modifications:

    • Improve sleep hygiene by maintaining a regular sleep schedule and creating a restful environment.

By following these tips, one can seamlessly integrate glycine into their daily routine, promoting better sleep and emotional stability. Proper usage of glycine, alongside other supportive measures like a well-regulated intake of sleep capsules and melatonin nasal sprays, can lead to substantial improvements in sleep and mood.

Frequently Asked Questions about Glycine

What is Glycine?

Glycine is a non-essential amino acid that plays a critical role in various physiological processes, including neurotransmission, immune response, and muscle function.

How does Glycine aid in sleep?

Glycine works by lowering body temperature and helping the body reach a state of relaxation, facilitating quicker and deeper sleep. It has a calming effect on the brain, enhancing overall sleep quality.

Can Glycine be taken in conjunction with other sleep aids?

Yes, Glycine can be combined with other natural sleep aids such as melatonin nasal spray, sleep capsules, or even bliss mood support supplements. However, it is crucial to consult a healthcare provider to ensure safe and effective use.

What is the recommended dosage for Glycine to improve sleep?

The recommended dosage for Glycine to aid sleep typically ranges from 3 to 5 grams. This dosage should ideally be taken 30 to 60 minutes before bedtime.

Are there any side effects associated with Glycine?

Glycine is generally well-tolerated. However, some individuals may experience mild gastrointestinal discomfort, including nausea or upset stomach. Consulting with a healthcare provider can help mitigate potential side effects.

How quickly can the effects of Glycine on sleep be noticed?

Most users report seeing improvements in sleep quality and latency within a few days of consistent use. Results may vary depending on individual conditions and overall health.

Is Glycine safe for long-term use?

Research indicates that Glycine is safe for long-term use when taken at the recommended dosages. Continuous monitoring and consultation with a healthcare provider are advisable, particularly for those with underlying health conditions.

Can Glycine improve mental clarity and cognitive function?

Yes, Glycine can enhance mental clarity and cognitive function. It acts as a neurotransmitter in the brain, influencing memory and learning processes. Its ability to improve sleep quality also indirectly supports cognitive health.

Should Glycine be taken with or without food?

Glycine can be taken with or without food based on personal preference. Taking it on an empty stomach may promote quicker absorption, but combining it with meals is also effective.

Are there specific populations that should avoid Glycine?

Individuals with kidney or liver diseases, pregnant or breastfeeding women should consult a healthcare provider before incorporating Glycine into their regimen. This ensures that Glycine use is appropriate and safe for their specific conditions.

Conclusion: The Future of Glycine as a Sleep Aid

As researchers continue to explore the efficacy of glycine in promoting better sleep, there are several aspects to consider. Glycine’s potential as a natural sleep aid is gaining traction due to its multifaceted benefits, which include enhancing sleep quality and cognitive function. Unlike other common sleep aids such as melatonin nasal sprays and sleep capsules, glycine offers a unique mechanism of action by targeting neurotransmitters in the brain, thereby fostering a state of calm and bliss mood support.

Future Research Directions

Several key areas need to be addressed to validate glycine’s long-term benefits:

1. Clinical Trials: Extended and larger-scale human trials are essential to corroborate existing findings and determine optimal dosages.
2. Comparative Studies: Comparing glycine’s efficacy with other sleep aids, such as melatonin nasal sprays and pharmaceutical sleep capsules, could provide more clarity.
3. Mechanisms of Action: Further understanding of how glycine influences neural pathways related to sleep can broaden its applications.

Market Potential

The growing interest in natural and holistic sleep remedies positions glycine favorably in the market. Supplements tailored for specific needs, such as glycine-inclusive sleep capsules, could offer consumers more targeted solutions. Additionally, glycine’s potential in supporting mental clarity and reducing cognitive fatigue can make it appealing for broader wellness products.

Consumer Awareness

To realize its full potential, increased consumer education is crucial. Highlighting glycine’s benefits in marketing materials and FAQs can inform potential users of its advantages over synthetic sleep aids. Articles, webinars, and endorsements by healthcare professionals can serve as valuable tools for spreading awareness.

Safety and Accessibility

Ensuring that glycine supplements meet safety standards will be critical. Accessibility and affordability will also influence its adoption. Companies must focus on transparent labeling and rigorous quality control to gain consumer trust.

Collaboration and Innovation

Partnerships between academic institutions, healthcare providers, and the nutraceutical industry can drive innovation. Areas of collaboration might include:

• Formulation Improvements: Developing glycine-based sleep capsules with enhanced bioavailability.
• Product Synergies: Combining glycine with other natural sleep aids for comprehensive support.

By addressing these factors, the future of glycine as a natural sleep aid looks promising.