NAD+ Nasal Spray

How NAD+ Functions in the Body

What Is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a naturally occurring coenzyme found in every living cell. It plays a central role in how your body converts nutrients into usable energy, maintains cellular repair systems, and regulates key biological processes associated with healthy aging.

Put simply: NAD+ helps your cells do their jobs efficiently.
When NAD+ levels are sufficient, cellular systems tend to run smoothly. When levels decline—as they naturally do with age, stress, poor sleep, and environmental load—those systems can feel strained.

Our NAD+ Nasal Spray is designed to support your body’s existing NAD+-dependent pathways, helping you maintain cellular function, metabolic efficiency, and cognitive clarity over time.

Core Functions of NAD+ in Human Biology

1. Supports Cellular Energy Production

One of NAD+’s most fundamental roles is its involvement in cellular energy metabolism. NAD+ acts as a critical electron carrier in mitochondrial processes that convert carbohydrates, fats, and proteins into ATP, the primary energy currency of the cell.

When NAD+ availability is adequate, cells are better equipped to:

- Maintain efficient energy production
- Respond to increased energy demands
- Support endurance and resilience at the cellular level

This function is foundational to why NAD+ is often associated with steady energy rather than stimulatory “peaks and crashes.”

2. Supports Mitochondrial Function

Mitochondria are often described as the “power plants” of the cell. NAD+ is essential for mitochondrial signaling and enzymatic activity, helping these organelles adapt to stress and metabolic demand.

Healthy mitochondrial function is associated with:

- Sustained physical and mental energy
- Efficient fuel utilization
- Long-term cellular resilience

By supporting NAD+ availability, this nasal spray helps reinforce the systems your mitochondria rely on to function optimally, especially important for people navigating high cognitive or physical demands.

3. Supports DNA Repair and Cellular Maintenance

NAD+ serves as a required cofactor for enzymes involved in DNA repair and cellular housekeeping, including PARPs and sirtuins. These enzymes help cells:

- Respond to everyday DNA stress
- Maintain genomic stability
- Regulate cellular longevity pathways

While DNA damage is a normal part of living, the body’s ability to repair and manage that damage depends in part on NAD+ availability. Supporting NAD+ levels helps ensure these maintenance systems have the resources they need to operate effectively.

4. Supports Cognitive Clarity and Neurological Function

The brain is one of the most metabolically active organs in the body, and one of the most sensitive to changes in cellular energy availability.

NAD+ plays a role in:

- Neuronal energy metabolism
- Neurotransmitter support pathways
- Cellular signaling involved in focus and mental clarity

By supporting energy production at the cellular level, NAD+ helps maintain the metabolic environment neurons depend on to function efficiently, making it a foundational nutrient for clarity, focus, and cognitive stamina.

5. Supports Healthy Aging Pathways

NAD+ is closely linked to biological processes associated with healthy aging, including sirtuin activity, metabolic regulation, and cellular stress response.

As NAD+ levels naturally decline over time, supporting these pathways becomes increasingly relevant for people who want to:

- Maintain performance as they age
- Support long-term cellular health
- Stay metabolically resilient under modern stressors

Rather than chasing short-term stimulation, NAD+ works quietly at the cellular level, supporting the systems that help your body adapt, recover, and restore balance.

Why Nasal Delivery Matters
Direct, Efficient Absorption

Unlike oral supplements that must pass through digestion and first-pass liver metabolism, nasal delivery allows nutrients to be absorbed through the highly vascular nasal mucosa. This route is widely used in both medical and wellness contexts to support faster, more efficient systemic availability.

For NAD+, this matters because:

- It avoids breakdown in the digestive tract
- It bypasses first-pass metabolism
- It supports more predictable absorption

The result is a delivery method designed to work with your biology, not against it.

Designed for Consistency, Not Spikes

Our NAD+ Nasal Spray is not intended to feel like a stimulant. Instead, it supports:

- Gradual cellular replenishment
- Steady metabolic support
- Compounding benefits with consistent use

This aligns with Synchronicity Health’s core philosophy: real results come from rhythm, not jolts.

How This Fits Into Your Sync Stack

NAD+ is often the foundation of a well-built Sync Stack. It pairs naturally with products that support:

- Antioxidant defense
- Neurotransmitter balance
- Sleep and recovery
- Metabolic efficiency

Whether used on its own or layered into a broader routine, NAD+ helps create the internal conditions your body needs to restore clarity, energy, and resilience over time.

Many customers start with NAD+ and build outward, adjusting their Sync Stack as their needs evolve.

What to Expect Over Time

Because NAD+ supports foundational cellular processes, its effects tend to be subtle at first and meaningful over time. With consistent use, people often report:

- More stable daily energy
- Improved mental clarity and focus
- Better tolerance to stress and busy schedules

As with all Synchronicity formulations, this product is designed for long-term support, not overnight transformation.

In Summary

The NAD+ Nasal Spray supports the body’s natural ability to:

- Produce cellular energy
- Maintain mitochondrial function
- Support DNA repair systems
- Regulate metabolic and neurological pathways
- Adapt to the demands of modern life

It doesn’t force outcomes. It supports the systems that already know what to do.

That’s what being in sync looks like.

Dispense two sprays intranasally, once or twice daily.

Tilt your head slightly, spray while gently inhaling. Leave it in the nose for 60 seconds before blowing to allow full absorption.

If spray hits the throat, inhale more gently next time.

- Nasal delivery for superior absorption — bypasses digestion to go straight to your bloodstream and brain
- Formulated in-house — every ingredient chosen for synergy and performance
- Backed by science — third-party tested, clinically aligned, clean ingredients only

This isn't just a boost. It's long-term support for people who want to stay clear, focused, and in control.

Nicotinamide Adenine Dinucleotide (NAD+) is essential for energy production, mitochondrial support, and healthy cellular aging — but levels naturally drop as we age, stress, and skimp on sleep.

What the decline looks like:
- You sleep eight hours but still wake up foggy.
- You eat well, but hit a wall by 2 p.m.
- You train hard, but struggle to recover or see progress.

Our NAD+ nasal spray replenishes what’s been depleted with fast, effective absorption designed to help you:
- Regain consistent, sustained energy
- Feel mentally sharper throughout the day
- Support your brain and body’s natural resilience

Formulated for Focus, Clarity, and Lasting Energy

Our Essential Sync Stack ™ — selected to bring your systems into alignment and support energy, clarity, and resilience at the source.

Per Serving (2 Sprays):

NAD+ –
Maximum Strength - 170mg/serving
Extra Strength - 100mg/serving
Regular Strength - 35mg/serving
The foundation for cellular energy and healthy aging.
Helps restore clarity, focus, and vitality when your energy feels off.

N-Acetyl-Cysteine (NAC) — A precursor to glutathione and powerful antioxidant support. Ideal for people exposed to stress, toxins, or inflammation.

Ascorbic Acid (Vitamin C) – Supports immune resilience and cellular repair.

Especially helpful if you feel rundown despite eating well.
Sodium Bicarbonate – Stabilizes pH and enhances absorption.
Ensures every dose works as effectively as possible.

Clinical Evidence Supporting NAD+ Nasal Spray
Introduction to NAD+ and Its Biological Importance

Nicotinamide adenine dinucleotide (NAD+) is a fundamental cellular coenzyme involved in essential biological processes including cellular energy metabolism, DNA repair, mitochondrial function, and redox signaling. NAD+ serves as a critical cofactor for sirtuins, PARPs (poly-ADP ribose polymerases), and other enzymes that regulate metabolic health, longevity pathways, and stress responses at the cellular level.
PMC

Multiple peer-reviewed studies have documented an age-related decline in NAD+ levels in human tissues, which has been implicated in metabolic dysfunction, reduced mitochondrial efficiency, and age-associated physiological changes.
ScienceDirect

Clinical Evidence for NAD+ Restoration Strategies

While NAD+ itself is not widely studied in large clinical trials in its native form, extensive research has focused on strategies to boost NAD+ availability in humans using precursors such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). These studies help establish the biological plausibility and mechanistic foundation for NAD+ augmentation, informing why delivery approaches that increase systemic NAD+ may have therapeutic relevance.

NAD+ Precursor Trials in Humans

Oral NR supplementation studies have consistently demonstrated that NR safely increases NAD+ levels in healthy adults, including trials showing dose-dependent increases in blood NAD+ and related metabolites.
OUP Academic

These studies also evaluated downstream effects on metabolic and mitochondrial markers, showing improved NAD+ metabolism over treatment periods up to several weeks.

Chronic NR and NMN interventions in human trials have explored effects on vascular, metabolic, inflammatory, and physical function endpoints. While sample sizes in these studies tend to be modest (often ≤40 participants), the data support that NAD+ boosting is well-tolerated and biologically active.
OUP Academic

Critically, these clinical investigations affirm safe augmentation of NAD+ pathways in humans and lay groundwork for exploring advanced delivery methods that may optimize systemic availability.

Rationale for Intranasal NAD+ Delivery

Traditional oral precursors are limited by first-pass metabolism and variable bioavailability. Intranasal delivery leverages the rich vascularization of the nasal mucosa to bypass gastrointestinal degradation and first-pass hepatic clearance, potentially offering faster absorption into systemic circulation and direct access to cerebrovascular pathways.

Although nasal administration of NAD+ itself is a newer therapeutic approach, and clinical trials specifically evaluating NAD+ nasal sprays in humans are currently limited, several converging bodies of evidence support its scientific rationale:

Mechanistic studies indicate that raising NAD+ levels systemically can positively influence cellular energy, repair pathways, and mitochondrial homeostasis, outcomes relevant to aging, neurological function, and metabolic regulation.
Nature

Reviews of NAD+ metabolism note that effective delivery strategies are a critical area of ongoing investigation to translate preclinical benefits into clinical outcomes.
Nature

Expert commentary consistently highlights that while NAD+ precursors increase NAD+ biosynthesis in humans, efficacy of alternative delivery systems (e.g., intranasal) remains an active area of early clinical and translational research.
Healthon

In sum, the scientific community acknowledges the biological significance of NAD+ and the potential advantages of non-oral routes of administration, while also recognizing the evolving state of targeted clinical data.

What the Clinical Evidence Shows and What It Doesn’t (Yet)

Demonstrated in Clinical Research:

✔ NAD+ levels decline with age, and this decline correlates with diminished metabolic and cellular functions.
ScienceDirect

✔ Oral NAD+ precursors such as NR and NMN safely increase NAD+ levels and show biological activity in human trials.
OUP Academic

✔ NAD+ augmentation is a promising therapeutic strategy supported by mechanistic and early translational evidence.
ScienceDirect

Ongoing Research and Future Directions

Leading experts emphasize that expanding clinical research into targeted NAD+ delivery methods, including intranasal, IV, and other advanced formulations, is an important frontier for aging, metabolic, and neurodegenerative disease biology.
Nature

Additionally, emerging work is focusing on how tissue-specific NAD+ metabolism and bioavailability differs across delivery routes, underscoring the need for robust clinical evaluation to fully define the therapeutic potential of nasal NAD+ formulations.
Nature

Conclusion

The clinical evidence base for NAD+ biology is strong in demonstrating the essential role of NAD+ in human health and the ability of precursor compounds to safely elevate systemic NAD+. Research into intranasal NAD+ delivery, including nasal sprays, is rapidly evolving, grounded in sound physiological rationale and supported by a growing understanding of NAD+ metabolism. As clinical trials progress, this delivery modality holds promise for efficient NAD+ augmentation and broad therapeutic application.

Notre source est toujours transparente. Nous n'utilisons aucun ingrédient qui n'a pas été testé par un tiers pour sa pureté, sa puissance, son contenu microbiologique, ses solvants résiduels et ses métaux lourds.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.