Cellular defense. Detoxification. Whole-body resilience.

Glutathione is often referred to as the body’s master antioxidant. It is produced naturally inside your cells and plays a central role in protecting against oxidative stress, supporting detoxification pathways, and maintaining immune and cellular health—especially during periods of high demand, environmental exposure, or recovery.

Primary Outcomes:

• Supports antioxidant defense
• Supports detoxification pathways
• Supports immune and cellular resilience

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What Is Glutathione?

Glutathione is a tripeptide composed of three amino acids: glutamate, cysteine, and glycine. Unlike many antioxidants that come only from diet, glutathione is synthesized inside the body and used within cells to neutralize oxidative stress and maintain redox balance.

Glutathione exists in two primary forms:

• Reduced glutathione (GSH) – the active antioxidant form
• Oxidized glutathione (GSSG) – the form after neutralizing free radicals

The body continually recycles glutathione between these two states to maintain cellular protection.

How Glutathione Works (Mechanism of Action)

1. Antioxidant Defense

Glutathione directly neutralizes reactive oxygen species (ROS) and helps regenerate other antioxidants, including vitamins C and E, amplifying overall antioxidant capacity.

2. Detoxification Support

Glutathione is essential for phase II liver detoxification, where it binds to toxins, heavy metals, and metabolic byproducts to support their safe elimination from the body.

3. Cellular Redox Balance

By maintaining an optimal ratio of reduced to oxidized glutathione, cells preserve redox homeostasis—critical for normal cellular signaling, mitochondrial function, and resilience under stress.

4. Immune Cell Function

Adequate intracellular glutathione levels are associated with proper immune cell signaling and response, particularly in high-turnover or high-stress environments.

Clinically Studied Dosage Ranges

Human research on glutathione focuses on both direct glutathione and precursors that support endogenous production.

Commonly Studied Human Ranges

• Oral glutathione: ~250–1,000 mg/day
• N-acetylcysteine (NAC) (a key precursor): ~600–1,800 mg/day

Intranasal Glutathione

Intranasal glutathione is an emerging delivery method designed to bypass digestion and support absorption, particularly for individuals who may not respond well to oral formats.

Benefits of Glutathione Support

Supports Antioxidant Protection

Glutathione helps neutralize oxidative stress generated by metabolism, environmental exposure, intense exercise, and everyday living.

Supports Detoxification Pathways

By participating in phase II conjugation, glutathione supports the body’s natural detoxification and elimination processes.

Supports Immune Health

Glutathione plays a role in immune cell activation, signaling, and balance, supporting the body’s ability to respond to stressors.

Supports Cellular & Mitochondrial Health

Maintaining adequate glutathione levels supports mitochondrial efficiency and protects cellular structures from oxidative damage.

Safety Profile

Glutathione and its precursors are generally well-tolerated in human studies when used within commonly studied ranges.

Potential side effects (typically mild and dose-dependent) may include:

• Gastrointestinal discomfort
• Headache

Intranasal considerations: Temporary nasal irritation may occur depending on individual sensitivity.

Consult a healthcare professional before use if you are:

• Pregnant or breastfeeding
• Managing a medical condition
• Taking prescription medications

Why Synchronicity Health’s Glutathione Is Different

Intranasal Delivery for Targeted Absorption

Traditional oral glutathione can be limited by digestive breakdown. Our intranasal glutathione is designed to bypass the GI tract, aligning with our focus on efficient, intentional delivery.

High-Purity, Clinically Informed Formulation

• Third-party tested ingredients
• No unnecessary fillers or proprietary blends
• Formulated for real-world consistency and tolerance

Formulated In-House

We formulate internally to ensure purity, dosing rationale, and delivery method align with our holistic approach to detoxification, recovery, and resilience.

Products Containing Glutathione

• Glutathione Nasal Spray

Frequently Asked Questions (SEO-Optimized)

What does glutathione do in the body?

Glutathione helps protect cells from oxidative stress, supports detoxification pathways, and plays a role in immune and cellular health.

Why is glutathione called the master antioxidant?

Because it works inside cells, neutralizes free radicals directly, and helps regenerate other antioxidants.

Is oral glutathione effective?

Results vary. Some individuals respond well, while others prefer alternative delivery methods or precursor support.

Why choose intranasal glutathione?

Intranasal delivery bypasses digestion and is designed to support more direct absorption.

Can glutathione support detox?

Glutathione is a key component of phase II detoxification and supports the body’s natural elimination processes.

Is glutathione safe for daily use?

Human research suggests good tolerability when used appropriately. Individual needs vary.

Can glutathione be stacked with other supplements?

Yes. It is commonly paired with precursors like NAC or with antioxidant and recovery-focused nutrients.