Kanna Nasal Spray

How Kanna + L-Theanine Function in the Body
What This Formula Is Designed to Support

The Kanna + L-Theanine Nasal Spray is formulated to support emotional balance, calm focus, and stress resilience, especially during moments of cognitive load, emotional pressure, or nervous system overactivation.

Rather than forcing stimulation or sedation, this formula works by supporting the body’s existing neurotransmitter and nervous system pathways, helping you feel more centered, clear, and emotionally steady.

Core Functions of Kanna (Sceletium tortuosum)
1. Supports Emotional Balance and Mood Stability

Kanna has a long history of traditional use for emotional well-being, and modern research suggests it interacts with neurotransmitter pathways involved in mood regulation and stress response.

By supporting balanced neurotransmitter signaling, Kanna helps the nervous system:

- Respond more proportionally to stressors
- Maintain emotional steadiness
- Avoid excessive emotional reactivity

This makes Kanna particularly relevant for people who feel mentally overstimulated, emotionally taxed, or “on edge”, rather than fatigued or low-energy.

2. Supports Stress Resilience Without Sedation

Unlike ingredients that blunt emotion or cause drowsiness, Kanna is considered non-sedating. Its role is not to suppress feeling—but to help the nervous system return to baseline more efficiently.

This function supports:

- Daytime use
- Situational stress support
- Emotional regulation without mental fog

The result is a calmer internal state that still feels alert and engaged.

3. Supports Cognitive Performance Under Stress

Stress can narrow attention, disrupt emotional regulation, and impair decision-making. Kanna supports cognitive processing during stress by helping regulate the neurochemical environment that influences focus and perception.

This can be particularly helpful during:

- High-pressure workdays
- Social or emotional demands
- Situations requiring calm decision-making

Core Functions of L-Theanine

1. Supports Calm Focus and Mental Clarity

L-theanine is widely studied for its ability to promote relaxation without drowsiness. It supports a calm, attentive mental state often described as “relaxed focus.”

This is achieved through its influence on:

- Alpha brain wave activity
- Excitatory and inhibitory neurotransmitter balance
- Mental clarity during cognitive demand

L-theanine does not stimulate. It helps quiet excess mental noise so focus can return naturally.

2. Supports Nervous System Regulation

L-theanine helps support balanced autonomic nervous system activity—particularly in moments of stress or overstimulation.

This function supports:

- Reduced perception of stress
- Improved stress tolerance
- A smoother transition from high alert to calm awareness

Rather than pushing the nervous system in one direction, L-theanine helps it self-regulate more effectively.

3. Supports Cognitive Performance Without Jitters

Unlike caffeine or other stimulants, L-theanine does not increase heart rate or create a “wired” feeling. Instead, it helps maintain clarity and composure, especially during mentally demanding tasks.

This makes it well suited for:

- Focused work
- Creative thinking
- Situations requiring emotional composure

Why Kanna and L-Theanine Work Better Together

Kanna and L-theanine support different but complementary aspects of stress physiology:

- Kanna focuses on emotional balance and neurotransmitter modulation
- L-theanine supports calm focus and nervous system regulation

Together, they help create a mental state that feels:

- Calm but not dull
- Focused but not tense
- Emotionally steady but still present

This synergy is ideal for people seeking clarity without stimulation and calm without sedation.

Why Nasal Delivery Matters
Efficient, Fast Absorption

Nasal delivery allows ingredients to be absorbed through the highly vascular nasal mucosa, bypassing digestion and first-pass liver metabolism.

This route is commonly used to support:

- Faster systemic availability
- More predictable absorption
- Situational or as-needed use

For a formula designed to support real-time emotional balance and calm clarity, nasal delivery is a deliberate and functional choice.

Designed for Situational Support and Daily Balance

This spray can be used:

- Before stressful events
- During mentally demanding days
- As part of a daily nervous system support routine

It is not habit-forming, stimulating, or sedating, making it suitable for consistent use.

How This Fits Into Your Sync Stack

Kanna + L-Theanine often plays a regulatory role in the Sync Stack, complementing products that support energy, cognition, or recovery.

It pairs especially well with:

- NAD+ for cellular energy and clarity
- Glutathione or NAC for stress and recovery support
- Sleep-focused formulations for nervous system balance across the full day

Many people use this spray during the midday stress window, high-pressure moments, or emotional transitions.

What to Expect With Consistent Use

Because this formula works with the nervous system rather than overriding it, the effects are often described as:

- Feeling calmer without feeling tired
- Improved emotional steadiness
- Clearer thinking under stress

The goal is not to change who you are, but to help you feel more like yourself when pressure is high.

In Summary

The Kanna + L-Theanine Nasal Spray supports the body’s ability to:

- Regulate emotional and stress responses
- Maintain calm focus and mental clarity
- Support balanced neurotransmitter signaling
- Navigate cognitive and emotional demands without overstimulation

It’s designed to help you move through your day with clarity, composure, and resilience, not force, hype, or suppression.

That’s nervous system support, done in sync.

To use our Kanna Nasal Spray, dispense two sprays intranasally. You will want to breathe in gently while you are dispensing the sprays. If the spray goes into the back of your throat, you inhaled too deeply or quickly. If this happens, try to be a bit more gentle with the inhale next time. After dispensing the nasal spray, tilt your head back slightly, and leave the Kanna Nasal Spray for at least 60 seconds before blowing your nose. Leaving the Kanna Nasal Spray in your nose for 60 seconds with ensure the best absorption. It is okay to take the Kanna Nasal Spray with or without a meal.

Per 2 Spray Serving: (Maximum Strength)
Proprietary Kanna Extract Blend 50mg

Other Ingredients: Reverse Osmosis Water,
Theanine, N-Acetyl-Cysteine, Ascorbic Acid, and Sodium Bicarbonate.

Per 2 Spray Serving: (Extra Strength)
Proprietary Kanna Extract Blend 35mg

Other Ingredients: Reverse Osmosis Water,
Theanine, N-Acetyl-Cysteine, Ascorbic Acid, and Sodium Bicarbonate.

Per 2 Spray Serving: (Regular Strength)
Proprietary Kanna Extract Blend 20mg

Other Ingredients: Reverse Osmosis Water,
Theanine, N-Acetyl-Cysteine, Ascorbic Acid, and Sodium Bicarbonate.

Clinical Evidence Supporting Kanna (Sceletium tortuosum) + L-Theanine Nasal Spray
Overview: Why Kanna and L-Theanine Are Used Together

Kanna (Sceletium tortuosum) is a traditional South African botanical with a long history of use for emotional balance, stress resilience, and mood support. Modern research has begun to clarify its unique effects on neurotransmitter signaling and stress response pathways.

L-theanine is a naturally occurring amino acid most commonly found in green tea. It has been extensively studied for its ability to support calm focus, relaxation without sedation, and healthy stress responses.

Together, Kanna and L-theanine form a complementary pairing:

Kanna supports emotional and cognitive balance through neurotransmitter modulation, while L-theanine supports nervous system calm and mental clarity.

Clinical Evidence on Kanna (Sceletium tortuosum)
Neurotransmitter Modulation and Stress Response

Modern pharmacological research indicates that standardized Kanna extracts influence neurotransmitter systems involved in mood and stress regulation. In particular, Kanna has been shown to interact with:

- Serotonin signaling pathways
- Phosphodiesterase-4 (PDE-4) activity
- Stress-related neurochemical responses

Human clinical studies using standardized Kanna extracts have demonstrated effects on perceived stress, emotional regulation, and cognitive processing under stress, supporting its traditional use as a calming, mood-supportive botanical.

Human Clinical Trials on Kanna

Several placebo-controlled human studies have evaluated standardized Kanna extracts in healthy adults:

Mood and emotional balance: Clinical trials have reported improvements in measures related to mood state, stress perception, and emotional resilience compared to placebo.

Cognitive and stress performance: Neuroimaging and psychometric studies suggest that Kanna may influence brain regions involved in emotional processing and stress response, without sedative effects.

Importantly, these trials characterize Kanna as non-sedating and well-tolerated, supporting its use for daytime emotional balance rather than drowsiness or suppression.

Safety and Tolerability

Published human studies report that standardized Kanna extracts are generally well tolerated when used as directed, with no serious adverse events noted in clinical settings. This safety profile has contributed to its growing use in modern wellness formulations focused on emotional regulation and stress support.

Clinical Evidence on L-Theanine
Calm Focus and Relaxation Without Sedation

L-theanine is one of the most extensively studied amino acids for stress and cognitive support. Human clinical trials consistently demonstrate that L-theanine promotes relaxation while preserving alertness.

Electroencephalography (EEG) studies show that L-theanine:

- Increases alpha brain wave activity
- Supports a calm yet attentive mental state
- Does not impair reaction time or cognitive performance

This makes L-theanine particularly well-suited for individuals seeking calm clarity rather than sedation.

Stress and Nervous System Regulation

Multiple placebo-controlled studies indicate that L-theanine supports:

- Reduced subjective stress responses
- Improved stress resilience during cognitively demanding tasks
- Balanced autonomic nervous system activity

These effects are thought to be mediated through modulation of glutamate signaling and support of inhibitory neurotransmitter activity.

Cognitive Performance Under Stress

Clinical research shows that L-theanine may help maintain:

- Attention and focus during mental strain
- Task performance under stressful conditions
- Mental clarity without stimulation

This has made L-theanine a common ingredient in formulations designed for calm productivity and emotional steadiness.

Why Combine Kanna and L-Theanine?

From a clinical perspective, Kanna and L-theanine address complementary aspects of stress physiology:

- Kanna supports emotional balance and neurotransmitter signaling associated with mood and stress response

- L-theanine supports nervous system calm, focus, and cognitive steadiness

Together, they offer layered support for emotional regulation, stress resilience, and mental clarity—without relying on stimulants or sedatives.

Rationale for Intranasal Delivery
Efficient Absorption and Rapid Availability

The nasal cavity is highly vascularized, allowing compounds to be absorbed efficiently while bypassing digestive breakdown and first-pass liver metabolism.

Intranasal delivery is widely used in both clinical and wellness contexts to:

- Support faster systemic availability
- Improve consistency compared to oral dosing
- Reduce variability related to digestion

For compounds like Kanna and L-theanine, often used for situational stress or emotional balance, this delivery method is particularly relevant.

Non-Sedating, Non-Stimulant Support

Unlike products that rely on caffeine, adaptogenic overstimulation, or sedative compounds, Kanna and L-theanine are supported by evidence showing calm, balanced effects without impairment.

This aligns with Synchronicity Health’s philosophy of supporting the nervous system rather than forcing it.

What the Clinical Evidence Clearly Supports

✔ Kanna has human clinical evidence supporting mood balance, emotional regulation, and stress resilience
✔ L-theanine is extensively studied for calm focus, relaxation, and stress support
✔ Both compounds are non-sedating and generally well tolerated
✔ Their mechanisms are complementary rather than redundant
✔ Intranasal delivery is a scientifically plausible route for efficient absorption

What Research Is Still Evolving

❗ Large-scale clinical trials evaluating combined Kanna + L-theanine intranasal formulations
❗ Long-term outcome data specific to nasal delivery
❗ Optimal timing and dosing strategies across different stress contexts

These are areas of active research interest, not gaps in biological plausibility.

Clinical Perspective

Kanna and L-theanine are not designed to blunt emotion or suppress stress entirely. Instead, clinical evidence supports their role in helping the nervous system respond more proportionally and recover more efficiently.

This makes them well suited for modern stress patterns—characterized by chronic cognitive load, emotional pressure, and constant stimulation—rather than acute emergencies.

Conclusion

The clinical evidence supporting both Kanna and L-theanine is substantial and growing. Human studies support their use for emotional balance, stress resilience, and calm cognitive function, with strong safety and tolerability profiles.

By combining these compounds in an intranasal delivery format, this formulation is designed to support efficient absorption, steady nervous system regulation, and clear emotional balance, without sedation, stimulation, or dependency.

As with all Synchronicity Health products, this approach prioritizes working with the body’s existing regulatory systems, not overriding them.

All of our ingredients are third-party party tested for purity, potency, microbiological content, residual solvents and heavy metals.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.