Enhanced NMN

How Enhanced NMN Capsules Function in the Body
What Enhanced NMN Is Designed to Support

Enhanced NMN (Nicotinamide Mononucleotide) Capsules are designed to support cellular energy production, metabolic efficiency, and healthy aging pathways by replenishing and protecting NAD+, a critical coenzyme required for cellular function.

This formula goes beyond NMN alone. It combines NMN with synergistic compounds that support NAD+ utilization, methylation balance, mitochondrial efficiency, and cellular protection—creating a more complete, system-level approach to cellular longevity and performance.

Core Functions of NMN

1. Supports NAD+ Production at the Cellular Level

NMN is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme involved in hundreds of enzymatic reactions related to energy metabolism, DNA repair, and cellular signaling.

Supporting NMN availability helps:

- Replenish declining NAD+ levels
- Support efficient cellular metabolism
- Reinforce foundational energy pathways

Because NAD+ levels naturally decline with age, stress, and metabolic load, NMN plays a key role in maintaining cellular vitality over time.

2. Supports Mitochondrial Function and Cellular Energy

NAD+ is essential for mitochondrial ATP production. By supporting NMN → NAD+ conversion, this formula helps:

- Improve mitochondrial efficiency
- Support steady cellular energy output
- Reduce metabolic fatigue

This energy support is cellular and sustainable, not stimulatory.

3. Supports DNA Repair and Cellular Maintenance

NAD+ is required for enzymes such as PARPs and sirtuins, which are involved in DNA repair, cellular cleanup, and stress response.

Supporting NMN pathways helps ensure cells have the resources needed to:

- Repair daily cellular damage
- Maintain genomic stability
- Adapt to metabolic and environmental stress

Functions of the Supporting Ingredients

Resveratrol - Supports Longevity and Sirtuin Activity

Resveratrol is a polyphenol studied for its role in activating sirtuins, a family of enzymes closely linked to longevity, metabolic regulation, and cellular stress resistance.

Resveratrol helps:

- Support sirtuin signaling pathways
- Reinforce NAD+-dependent cellular repair mechanisms
- Support mitochondrial and metabolic resilience

In this formula, resveratrol works synergistically with NMN, helping ensure newly replenished NAD+ is effectively utilized in longevity-associated pathways.

Pterostilbene - Supports Cellular Protection and Bioavailability

Pterostilbene is a structural analog of resveratrol with enhanced bioavailability and cellular uptake. It provides antioxidant and cellular protection support while reinforcing metabolic signaling.

Pterostilbene supports:

- Cellular defense against oxidative stress
- Mitochondrial and metabolic health
- Long-term cellular resilience

Together, resveratrol and pterostilbene help protect the cellular environment in which NAD+ operates.

Trimethylglycine (TMG) - Supports Methylation Balance

As NAD+ production increases, the body’s methylation demand can increase as well. Trimethylglycine (also known as betaine) supports healthy methyl group availability.

TMG helps:

- Support balanced methylation pathways
- Reduce metabolic strain associated with NAD+ turnover
- Maintain homocysteine metabolism

Including TMG helps ensure NMN supplementation remains balanced and sustainable for long-term use.

Methyl B12 - Supports Neurological and Cellular Energy Pathways

Vitamin B12 is essential for:

- Methylation and cellular replication
- Neurological signaling
- Red blood cell and energy metabolism

Using methylcobalamin, the bioactive form of B12, helps support:

- Nervous system function
- Cellular energy production
- Efficient methylation alongside TMG

Methyl B12 further reinforces the metabolic and neurological benefits of NMN supplementation.

Why This Enhanced Formula Matters

NMN does not work in isolation. Effective NAD+ support requires:

- Precursors (NMN)
- Utilization support (resveratrol, pterostilbene)
- Methylation balance (TMG, methyl B12)
- Cellular protection

By addressing all of these layers, Enhanced NMN Capsules support NAD+ replenishment that is efficient, balanced, and sustainable.

How Enhanced NMN Fits Into Your Sync Stack

Enhanced NMN Capsules often serve as a core longevity and energy foundation within the Sync Stack.

They pair especially well with:

- NAD+ Nasal Spray for situational support
- Clarity Capsules for cognitive performance
- OEA or Berberine for metabolic regulation
- Sleep formulations to support overnight cellular repair

Many people use Enhanced NMN daily as a baseline, layering other products based on lifestyle and demand.

What to Expect With Consistent Use

Because this formula supports foundational cellular processes, benefits are typically:

- Gradual and cumulative
- Most noticeable over weeks rather than days
- Experienced as improved consistency and resilience
- Commonly reported experiences include:
- More stable energy
- Improved recovery and stamina
- Better tolerance to physical and cognitive stress

In Summary

Enhanced NMN Capsules support the body’s ability to:

- Replenish and utilize NAD+ effectively
- Produce cellular energy efficiently
- Support DNA repair and longevity pathways
- Maintain methylation balance
- Protect cells from metabolic and oxidative stress

They don’t force performance.
They support the systems that make performance sustainable.

That’s longevity support, done in sync.

Take 2 capsules in the morning with or without food. For best results, use daily.

Pro tip: Pair with NAD+ Nasal Spray for dual-phase support — fast-acting clarity + long-lasting energy.

NMN is a direct precursor to NAD+ — the coenzyme your body needs for nearly every cellular function: energy metabolism, cognitive performance, DNA repair, and more. But NAD+ levels drop as we age, and stress, poor sleep, and environmental toxins accelerate the decline.

Supplementing with high-quality NMN can help reverse that loss — naturally restoring your energy, recovery, and resilience from the inside out.

Formulated for Energy, Resilience & Absorption
Every Synchronicity product starts with our Essential Sync Stack™ — ingredients chosen for their synergy, purity, and performance.

Per Serving (2 Capsules):

- NMN (Nicotinamide Mononucleotide) – 750mg
Powers cellular energy by raising NAD+ levels. Supports focus, metabolism, and healthy aging.

- Trimethylglycine – 200mg

- Resveratrol – 200mg

- Pterostilbene – 100mg

- Vitamin B12 (Methylcobalamin) - 750mcg 31,250%

- Vegan Capsule

No synthetic fillers. No dyes. Always third-party tested.

Clinical Evidence Supporting Enhanced NMN Capsules
Overview: NAD+ Decline Is a Systems-Level Issue

Nicotinamide adenine dinucleotide (NAD+) is a central coenzyme required for cellular energy production, DNA repair, metabolic regulation, and stress adaptation. A large and growing body of scientific literature demonstrates that NAD+ levels decline with age, chronic stress, and metabolic demand, contributing to reduced cellular efficiency and resilience.

Modern longevity and metabolic research increasingly recognizes that supporting NAD+ is not just about increasing precursors, but about ensuring:

- Efficient NAD+ synthesis
- Effective NAD+ utilization
- Balanced methylation during NAD+ turnover
- Protection of cellular systems under increased metabolic activity

Enhanced NMN Capsules were designed to address all of these layers simultaneously, based on converging clinical and mechanistic evidence.

Clinical Evidence on NMN and NAD+ Replenishment
NMN as a Direct NAD+ Precursor

NMN (nicotinamide mononucleotide) is a naturally occurring intermediate in the NAD+ salvage pathway. Extensive preclinical and human research demonstrates that NMN:

- Is efficiently converted into NAD+ in tissues
- Supports restoration of declining NAD+ levels
- Improves cellular energy metabolism and mitochondrial function

Human clinical studies have shown that NMN supplementation can increase NAD+ metabolites, support metabolic efficiency, and improve markers related to energy utilization, without acting as a stimulant.

These findings establish NMN as a biologically direct and well-supported strategy for NAD+ replenishment.

NAD+ and Cellular Energy, Repair, and Longevity Pathways

NAD+ is required for:

- Mitochondrial ATP production
- Sirtuin activity (cellular stress resistance and longevity pathways)
- PARP-mediated DNA repair
- Redox balance and metabolic signaling

When NAD+ availability is limited, these systems compete for resources. Restoring NAD+ helps reduce metabolic friction and supports coordinated cellular function across tissues with high energy demand, including muscle, brain, and liver.

Clinical Evidence on Resveratrol and Pterostilbene
Resveratrol and Sirtuin Activation

Resveratrol is a polyphenol extensively studied for its role in activating sirtuins, a family of NAD+-dependent enzymes involved in:

- Cellular repair and maintenance
- Stress resistance
- Mitochondrial biogenesis
- Metabolic regulation

Clinical and mechanistic research demonstrates that resveratrol:

- Enhances NAD+-dependent signaling
- Supports metabolic and mitochondrial health
- Reinforces longevity-associated pathways

Importantly, resveratrol does not increase NAD+ on its own, it helps ensure that newly replenished NAD+ is actively used in protective and adaptive cellular processes.

Pterostilbene: Enhanced Bioavailability and Cellular Protection

Pterostilbene is a structural analog of resveratrol with greater bioavailability and cellular uptake, making it particularly effective for long-term cellular support.

Research indicates that pterostilbene:

- Supports antioxidant and redox balance
- Reinforces mitochondrial integrity
- Supports metabolic and cellular resilience

When paired with resveratrol, pterostilbene helps extend and stabilize polyphenol-mediated support of NAD+-dependent pathways.

Clinical Evidence on Methylation Support (TMG + Methyl B12)
Why Methylation Matters with NAD+ Support

NAD+ metabolism intersects directly with methylation pathways, particularly through the conversion of nicotinamide (a NAD+ breakdown product) into metabolites that require methyl groups.

Clinical and biochemical research shows that:

- Increased NAD+ turnover can increase methyl group demand
- Insufficient methylation support may create metabolic strain over time
- Balanced methylation is essential for long-term sustainability of NAD+ strategies

This is why advanced NAD+ formulations increasingly include methylation support.

Trimethylglycine (TMG)

Trimethylglycine (betaine) is a well-studied methyl donor that supports:

- Homocysteine metabolism
- Methyl group availability
- Efficient cellular methylation balance

Including TMG helps ensure that NAD+ replenishment remains metabolically balanced, particularly during consistent, long-term NMN use.

Methyl B12 (Methylcobalamin)

Vitamin B12 is a critical cofactor in:

- Methylation cycles
- DNA synthesis
- Neurological function
- Cellular energy metabolism

Methylcobalamin is the bioactive form used directly by the body. Clinical evidence shows that adequate B12 status is essential for:

- Supporting methylation efficiency
- Maintaining neurological and cognitive function
- Supporting red blood cell and energy metabolism

Together, TMG and methyl B12 help reinforce the metabolic infrastructure required for sustainable NAD+ support.

Why This Combination Is Clinically Coherent

From a clinical systems perspective, NAD+ support requires more than a single ingredient. The combination used in Enhanced NMN Capsules addresses four interconnected biological needs:

NAD+ Replenishment → NMN

NAD+ Utilization & Longevity Signaling → Resveratrol + Pterostilbene

Methylation Balance During NAD+ Turnover → TMG + Methyl B12

Cellular Protection Under Increased Metabolic Activity → Polyphenols + B Vitamins

This integrated approach is supported by current research trends in aging, metabolism, and mitochondrial health, which emphasize coordination rather than isolated interventions.

Safety and Tolerability

All ingredients in Enhanced NMN Capsules have been studied extensively in human clinical or translational research contexts and are generally well tolerated when used as directed.

Notably:

- The formula is non-stimulant
- It does not artificially elevate energy or nervous system activity
- It is designed for consistent, long-term use, not cycling or escalation
- This safety profile aligns with its role as a foundational cellular support strategy.

What the Clinical Evidence Clearly Supports

✔ NMN effectively supports NAD+ replenishment
✔ NAD+ is central to cellular energy, repair, and longevity pathways
✔ Resveratrol and pterostilbene support NAD+-dependent enzyme activity
✔ Methylation demand increases with NAD+ turnover
✔ TMG and methyl B12 support balanced methylation and sustainability
✔ Multi-pathway NAD+ support is more biologically coherent than single-ingredient approaches

What Research Is Still Evolving

❗ Long-term outcome data in large, diverse healthy populations
❗ Individual variability in optimal NAD+ support strategies
❗ Comparative studies of combined vs. single-ingredient NAD+ formulations

These represent active areas of research, not uncertainty about foundational mechanisms.

Clinical Perspective

From a clinical standpoint, the goal of NAD+ support is not short-term energy, it is cellular resilience.

Enhanced NMN Capsules are formulated to:

- Restore declining NAD+
- Ensure that NAD+ is effectively used
- Maintain metabolic balance during increased cellular activity

This reflects modern longevity science: support the system, not just the signal.

Conclusion

The scientific evidence supporting NMN, resveratrol, pterostilbene, trimethylglycine, and methyl B12 is robust and complementary. Together, these ingredients support NAD+ replenishment, utilization, and sustainability, addressing the full lifecycle of cellular energy and repair.

Enhanced NMN Capsules are built on the principle that longevity and performance are the result of coordinated biology, not isolated interventions.

As with all Synchronicity Health formulations, this product is designed to work with the body’s intelligence, supporting resilience, efficiency, and long-term vitality.

All of our ingredients are third-party party tested for purity, potency, microbiological content, residual solvents and heavy metals.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.