If you’ve been feeling a little off—foggy, underpowered, or like your energy doesn’t match your ambition—NAD+ is one of the most foundational molecules your body uses to get back in sync. It’s present in every cell, and it sits at the crossroads of cellular energy, recovery, and resilience. PMC+1

What it is

NAD+ is a naturally occurring coenzyme found in all living cells. Think of it as a cellular “currency” your body uses to convert nutrients into usable energy and to help manage everyday wear-and-tear at the cellular level. PMC+1

NAD+ exists in two primary forms:

• NAD+ (oxidized)
  
• NADH (reduced)
  

Your body continually cycles between these forms to keep metabolism and cellular function running smoothly. PMC+1

How it works (mechanism)

NAD+ supports cellular function through a few major pathways:

1) Energy production (mitochondrial metabolism)

NAD+ helps shuttle electrons in key metabolic reactions that ultimately drive ATP production—your cells’ usable energy. PMC+1

2) Cellular repair + stress response signaling

NAD+ is also consumed by enzymes involved in repair and regulation, including:

• Sirtuins (cellular stress response and metabolic regulation)
  
• PARPs (DNA repair signaling)
  
• CD38 (a major NAD-consuming enzyme that influences NAD availability)
  

Because these systems use up NAD+, maintaining healthy NAD+ availability is part of supporting long-term cellular performance. PMC+1

3) “NAD economy” and healthy aging research

A large body of research explores how NAD+ biology relates to normal changes over time and how “NAD-boosting” strategies (often via precursors like NR or NMN) can influence NAD-related metabolites in humans. OUP Academic+1

Clinically studied dosage ranges

Important nuance: Most human clinical research focuses on NAD+precursors (nutrients the body converts into NAD+), such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—not always “straight NAD+” taken orally. OUP Academic+1

That said, here are clinically studied ranges commonly seen in humans:

NAD+ precursors (most human data)

• NR: commonly studied from 100 mg/day up to 1,000 mg/day (including studies examining NAD metabolite changes in humans). kgkscience.com+1
  
• NMN: commonly studied in the 250–1,250 mg/day range in published human trials and safety reviews. ScienceDirect
  

Direct NAD+ (route matters)

• Intranasal NAD+ has limited published evidence (including case-level reporting). This is an emerging area and not as well-established as oral precursor research. Fagron Academy+1
  

Benefits (with citations)

Because NAD+ is foundational, benefits are typically discussed as supporting normal function rather than “treating” anything. The best-supported human outcomes tend to be:

Supports cellular energy metabolism

NAD+ is central to redox reactions that power metabolic pathways and mitochondrial energy production. PMC+1

Supports DNA repair pathways and cellular resilience

NAD+ is required for PARP activity and other NAD-dependent systems involved in cellular maintenance and stress response signaling. PMC+1

NAD+ precursors can increase NAD-related metabolites in humans

Human studies and reviews report that NAD-boosting strategies (notably NR, and NMN in several trials) can raise NAD+ or NAD-related metabolites in blood, with ongoing research into functional outcomes. OUP Academic+2kgkscience.com+2

Translation for customers: NAD+ sits upstream of the “steady energy” people want—less of a spike, more of a baseline you can build on over time.

Safety profile

In human research on NAD+ boosting (especially via NR/NMN), supplementation is generally reported as well-tolerated in the short-to-medium term, with adverse events often similar to placebo in controlled trials and reviews—though long-term, large-scale data is still evolving. OUP Academic+2Tru Niagen+2

Possible side effects (vary by person, dose, and route) may include:

• Mild gastrointestinal discomfort (nausea, upset stomach)
  
• Headache or flushing-like sensations (more commonly discussed with certain B3 forms, not all NAD strategies)
  
• For intranasal formats: potential transient nasal irritation (route-dependent; individual tolerance varies)
  

Who should be cautious / talk to a clinician first:

• Pregnant or breastfeeding individuals
  
• People with significant medical conditions or those taking prescription medications
  
• Anyone preparing for surgery or with complex health history
  

Why Synchronicity’s NAD+ is different

Most brands sell ingredients. We build systems—formulations designed to work with your biology, not against it.

Here’s what that means for NAD+:

Designed for absorption (intranasal delivery)

Oral delivery can be limited by digestion and first-pass metabolism. Intranasal delivery is designed to bypass the GI tract—a route many people choose when they want a more direct option. (Research on intranasal NAD+ is still early, but the route is a key part of our design philosophy.) Fagron Academy+1

Clean inputs, quality-first sourcing

Synchronicity products are built around:

• Third-party tested ingredients
  
• No mystery blends
  
• Intentional formulation for synergy and real-world use
  

In-house formulation (not white-labeled)

We don’t slap a label on a generic formula. We formulate in-house so the dose strategy, ingredient pairings, and delivery method align with the outcome we’re actually targeting: steadier clarity and energy you can sustain.

Products that contain NAD+

• NAD+ Nasal Spray
  
• Clarity Nasal Spray
  

FDA disclaimer

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.