Anandamide Supplement

Mood regulation can be described as our ability to effectively manage emotional responses in different situations and contexts. Impairment of this ability can be caused by a multitude of reasons, and can result in difficulty shifting out of "negative" emotional states such as sadness or anxiousness into neutral or more "positive" emotional states such as happiness, calmness, etc. Our Anandamide Supplement is specifically designed to help shift you into a more happy and relaxed emotional state:


Anandamide:
- Mood Regulation: Anandamide is sometimes referred to as the "bliss molecule" due to its role in regulating mood and promoting feelings of well-being.
- Pain Management: Anandamide supplements may also contribute to pain modulation and inflammation control.

Palmitoylethanolamide (PEA):
- Anandamide Synergist: PEA helps boost the physiological effects of anandamide by inhibiting its breakdown.
- Mood Regulation: PEA may also possess its own mood-boosting properties, independent of its effects on anandamide.

Oleoylethanolamide (OEA):
- Anandamide Supplement Synergist: OEA helps boost the physiological effects of anandamide by inhibiting its breakdown.

Theanine:
- Stress Reduction: Theanine is an amino acid found in tea leaves, known for its ability to reduce stress and promote relaxation.
- Stress Management: Theanine can help alleviate the effects of stress by influencing neurotransmitters in the brain, particularly by increasing the levels of gamma-aminobutyric acid (GABA), which has calming effects.


These four ingredients in our Anandamide Supplement help support mood regulation, pain management, stress reduction, and overall well-being. It is important to follow recommended dosages and consult with a healthcare provider, especially if you have specific health concerns or are taking medications.

Suggested Use: Two (2) capsules daily, taken in the morning with or without food, or as recommended by your healthcare practitioner.

Per 2 Capsule Serving:
Anandamide 600mg
Palmitoylethanolamide 150mg
Oleoylethanolamide 100mg
Theanine 100mg

Organic Absorption & Utilization Blend 300mg:
Sunflower Lecithin, Ginger Extract, Black Pepper Extract.

--Anandamide is an endogenous cannabinoid compound, meaning that it is naturally produced in the body as a part of the endocannabinoid system (ECS)--a complex cell-signaling system that plays a role in regulating a variety of functions and processes. Research has identified it as one of the compounds primarily responsible for the famous post-exercise feelings of happiness popularly called the "runner's high", with multiple studies indicating that anandamide may promote feelings of happiness and well-being. Preclinical studies suggest anandamide as a candidate to provide relief for symptoms of mood disorders. An Anandamide Supplement may also offer benefits in providing pain relief, appetite regulation, neuroprotection, memory support, anti-inflammatory properties, and sleep regulation. 1

--Palmitoylethanolamide (PEA) is an endocannabinoid-like fatty acid amide that is found in various foods and is naturally produced in the body. It is known to enhance the physiological effects of anandamide by preventing its enzymatic degradation via fatty acid amide hydrolase (FAAH)--a phenomenon termed the "entourage effect". Research suggests that it may possess its own mood regulation properties independent of its potentiation effects on anandamide as well, with multiple preclinical studies and one human clinical trial in patients with major depressive disorder showing positive results. PEA may also offer benefits in providing pain relief, neuroprotection, cognitive function support, anti-inflammatory properties, and improved gut health. 2

--Oleoylethanolamide (OEA) is an endocannabinoid-like fatty acid amide that is found in various foods and is naturally produced in the body. It is known to enhance the physiological effects of anandamide by preventing its enzymatic degradation via fatty acid amide hydrolase (FAAH)--a phenomenon termed the "entourage effect". OEA may also offer benefits in appetite suppression, weight management, lipid metabolism, improved gut health, anti-inflammatory effects, neuroprotective properties, and enhanced memory function. 3

--L-Theanine is an amino acid found in high amounts in various species of tea leaves (especially green teas) as well as some species of mushrooms. It is an analogue of the amino acids L-glutamine and L-glutamate, meaning that it is structurally similar, but contains some small differences that lead to different physiological effects. L-theanine has been shown to exhibit calming and stress-relieving effects without causing sedation or drowsiness, via its impact on levels of various neurotransmitters. Research also suggests that these effects on neurotransmitter levels may help boost mood directly, which has prompted investigations into its potential benefits for alleviating symptoms of depression. L-theanine may also offer benefits in enhancing sleep quality, cognitive function, and neuroprotection. 4

*While these potential benefits sound promising, more comprehensive human studies are needed to confirm them. In addition, the effects of these compounds can vary based on several factors, including dosage, inter-individual physiological differences, and the presence of other exogenous compounds. It is important to consult a health care professional before starting a new supplement--particularly if you have been diagnosed with a medical condition and/or are taking medication or other exogenous substances--to ensure that no contraindications or potential for adverse reactions may exist.


References:

1. Gallego-Landin I, García-Baos A, Castro-Zavala A, Valverde O. Reviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression. Front Pharmacol. 2021 Dec 6;12:762738. doi: 10.3389/fphar.2021.762738. PMID: 34938182; PMCID: PMC8685322.

2. Clayton P, Hill M, Bogoda N, Subah S, Venkatesh R. Palmitoylethanolamide: A Natural Compound for Health Management. Int J Mol Sci. 2021 May 18;22(10):5305. doi: 10.3390/ijms22105305. PMID: 34069940; PMCID: PMC8157570.

3. Ho WS, Barrett DA, Randall MD. 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol. 2008 Nov;155(6):837-46. doi: 10.1038/bjp.2008.324. Epub 2008 Aug 11. PMID: 18695637; PMCID: PMC2597234.

4. Williams JL, Everett JM, D'Cunha NM, Sergi D, Georgousopoulou EN, Keegan RJ, McKune AJ, Mellor DD, Anstice N, Naumovski N. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant Foods Hum Nutr. 2020 Mar;75(1):12-23. doi: 10.1007/s11130-019-00771-5. PMID: 31758301.

All of our ingredients are third-party party tested for purity, potency, microbiological content, residual solvents and heavy metals.