Lion's Mane Mushroom Blend

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Lion's Mane (Hericium erinaceus):
- Neuroprotection: Lion's Mane is renowned for its neuroprotective properties. It contains compounds known as erinacines and hericenones that stimulate nerve growth factor (NGF) production, potentially aiding in the growth and repair of nerve cells in the brain. This can contribute to improved cognitive function and memory.
- Cognitive Enhancement: Lion's Mane has been studied for its potential to enhance cognitive function, particularly in terms of memory, focus, and mental clarity.
- Mood Regulation: Some research suggests that Lion's Mane may have mood-regulating effects, which can help reduce symptoms of anxiety and depression.

Alpha GPC (Alpha-Glycerophosphocholine):
- Choline Source: Alpha GPC is a highly bioavailable choline compound. Choline is a precursor to acetylcholine, a neurotransmitter that plays a crucial role in memory, learning, and cognitive function.
- Cognitive Support: Alpha GPC is known for its potential to support cognitive function. It can enhance memory, attention, and overall mental performance, making it a valuable component in cognitive enhancement supplements.
- Neuroprotective: Alpha GPC may provide neuroprotective effects, helping to safeguard brain cells from damage and promoting brain health.

Phenylethylamine (PEA):
- Neurotransmission: Phenylethylamine is a natural compound that acts as a neuromodulator and a neurotransmitter in the central nervous system. It plays a role in mood regulation and emotional well-being.
- Mood Elevation: PEA is often associated with mood elevation and increased feelings of pleasure and happiness. It is thought to stimulate the release of endorphins and other 'feel-good' neurotransmitters.
- Focus and Alertness: PEA can enhance focus and alertness, potentially improving cognitive performance. It may also help increase attention span and concentration.

When combined, these ingredients in Lion's Mane Blend work synergistically to support and enhance cognitive function, offering a well-rounded approach to mental clarity, memory, mood, and overall brain health. The proprietary organic absorption and utilization blend further optimizes the delivery of these compounds, making the product even more effective. This is why we believe that Synchronicity Health has the best lion's mane supplement.

Take two capsules daily, with or without food, or as recommended by your healthcare practitioner.

Per 2 Capsule Serving:
Lion's Mane 8:1 Fruiting Body Extract 500mg
Alpha-GPC 300mg
Phenylethylamine 300mg

Organic Absorption & Utilization Blend 200mg:
Sunflower Lecithin, Ginger Extract, Black Pepper Extract.

Lion's mane (Hericium erinaceus), alpha-GPC (alpha-glycerophosphocholine), and phenylethylamine (PEA) have been studied for their effects on brain health and cognition.

Lion's mane has shown potential in improving brain health and cognitive function. Research suggests that Lion's mane may have neuroprotective effects and promote nerve cell growth and regeneration (Friedman, 2015)Lee et al., 2022). It has also been associated with improvements in memory and learning (Erickson et al., 2011). Additionally, Lion's mane has been found to possess antioxidant and anti-inflammatory properties, which may contribute to its beneficial effects on brain health (Friedman, 2015).

Alpha-GPC is a compound that has been investigated for its cognitive-enhancing properties. It has been shown to increase acetylcholine levels in the brain, which is important for memory and learning (Amenta & Tayebati, 2008). Studies have found that alpha-GPC supplementation can improve cognitive function, attention, and mental performance (Scapicchio, 2013). It has also been suggested that alpha-GPC may have neuroprotective effects and support brain health (Scapicchio, 2013).

Phenylethylamine (PEA) is a compound that is naturally produced in the body and is involved in mood regulation. While there is limited research specifically on the effects of PEA on brain health and cognition, it has been implicated in the antidepressant effects of exercise (Hillman et al., 2008). Physical exercise has been shown to increase PEA levels, and higher levels of PEA have been associated with improved mood and reduced symptoms of depression (Hillman et al., 2008).

In summary, Lion's mane, alpha-GPC, and phenylethylamine have shown potential in supporting brain health and cognitive function. Lion's mane may have neuroprotective effects and promote nerve cell growth and regeneration. Alpha-GPC has been found to enhance cognitive function and support brain health. Phenylethylamine may be involved in the antidepressant effects of exercise. However, further research is needed to fully understand the mechanisms of action and the specific effects of these compounds on brain health and cognition.

References:
Amenta, F. and Tayebati, S. (2008). Pathways of acetylcholine synthesis, transport and release as targets for treatment of adult-onset cognitive dysfunction. Current Medicinal Chemistry, 15(5), 488-498. https://doi.org/10.2174/092986708783503203
Baba, Y., Inagaki, S., Nakagawa, S., Kobayashi, T., Kobayashi, M., & Takihara, T. (2021). Effects of l-theanine on cognitive function in middle-aged and older subjects: a randomized placebo-controlled study. Journal of Medicinal Food, 24(4), 333-341. https://doi.org/10.1089/jmf.2020.4803
Camfield, D., Stough, C., Farrimond, J., & Scholey, A. (2014). Acute effects of tea constituents l-theanine, caffeine, and epigallocatechin gallate on cognitive function and mood: a systematic review and meta-analysis. Nutrition Reviews, 72(8), 507-522. https://doi.org/10.1111/nure.12120
Chong, P., Fung, M., Wong, K., & Lim, L. (2019). Therapeutic potential of hericium erinaceus for depressive disorder. International Journal of Molecular Sciences, 21(1), 163. https://doi.org/10.3390/ijms21010163
Erickson, K., Voss, M., Prakash, R., Basak, C., Szabo, A., Chaddock, L., … & Kramer, A. (2011). Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences, 108(7), 3017-3022. https://doi.org/10.1073/pnas.1015950108
Evans, M., McDonald, A., Xiong, L., Crowley, D., & Guthrie, N. (2021). A randomized, triple-blind, placebo-controlled, crossover study to investigate the efficacy of a single dose of alphawave® l-theanine on stress in a healthy adult population. Neurology and Therapy, 10(2), 1061-1078. https://doi.org/10.1007/s40120-021-00284-x
Friedman, M. (2015). Chemistry, nutrition, and health-promoting properties of hericium erinaceus (lion’s mane) mushroom fruiting bodies and mycelia and their bioactive compounds. Journal of Agricultural and Food Chemistry, 63(32), 7108-7123. https://doi.org/10.1021/acs.jafc.5b02914
Hillman, C., Erickson, K., & Kramer, A. (2008). Be smart, exercise your heart: exercise effects on brain and cognition. Nature Reviews Neuroscience, 9(1), 58-65. https://doi.org/10.1038/nrn2298
Lardner, A. (2013). Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders. Nutritional Neuroscience, 17(4), 145-155. https://doi.org/10.1179/1476830513y.0000000079
Lee, S., Hsu, J., Chen, T., Huang, C., Wu, T., & Chin, T. (2022). Erinacine a prevents lipopolysaccharide-mediated glial cell activation to protect dopaminergic neurons against inflammatory factor-induced cell death in vitro and in vivo. International Journal of Molecular Sciences, 23(2), 810. https://doi.org/10.3390/ijms23020810
Manganyi, M., Bezuidenhout, C., Regnier, T., & Ateba, C. (2021). A chewable cure “kanna”: biological and pharmaceutical properties of sceletium tortuosum. Molecules, 26(9), 2557. https://doi.org/10.3390/molecules26092557
Mori, K., Obara, Y., Moriya, T., Inatomi, S., & Nakahata, N. (2011). Effects of hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Biomedical Research, 32(1), 67-72. https://doi.org/10.2220/biomedres.32.67
Park, D. and Reuter‐Lorenz, P. (2009). The adaptive brain: aging and neurocognitive scaffolding. Annual Review of Psychology, 60(1), 173-196. https://doi.org/10.1146/annurev.psych.59.103006.093656
Robinson, O., Vytal, K., Cornwell, B., & Grillon, C. (2013). The impact of anxiety upon cognition: perspectives from human threat of shock studies. Frontiers in Human Neuroscience, 7. https://doi.org/10.3389/fnhum.2013.00203
Scapicchio, P. (2013). Revisiting choline alphoscerate profile: a new, perspective, role in dementia?. International Journal of Neuroscience, 123(7), 444-449. https://doi.org/10.3109/00207454.2013.765870
Stern, Y. (2012). Cognitive reserve in ageing and alzheimer's disease. The Lancet Neurology, 11(11), 1006-1012. https://doi.org/10.1016/s1474-4422(12)70191-6
Szabo, A. (2001). Phenylethylamine, a possible link to the antidepressant effects of exercise?. British Journal of Sports Medicine, 35(5), 342-343. https://doi.org/10.1136/bjsm.35.5.342

All of our ingredients are third-party party tested for purity, potency, microbiological content, residual solvents and heavy metals.

These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure,
or prevent any disease.

Our "Functions" and "Clinical Evidence" sections are based on scientific studies sourced from Pubmed, a trusted source, for informational purposes only and are not intended to be claims regarding our products.