Best Anandamide Supplement: How to Choose One That Delivers

The best anandamide supplement is one whose label shows exactly what you get: the amount of anandamide and of every partner ingredient, such as PEA and OEA, with no proprietary blend hiding the numbers. Look for third-party tested ingredients, no CBD or THC if you want to avoid them, a simple daily serving and a fair price per serving. Our Anandamide Supplement gives 600 mg of anandamide, 150 mg of PEA, 100 mg of OEA and 100 mg of L-theanine in every 2-capsule serving.

Key Takeaways

• Anandamide is an endocannabinoid your body makes on its own; it was identified in 1992 as a natural compound that binds the brain's cannabinoid receptor (Devane et al., 1992).
• Anandamide supplements usually pair anandamide with its chemical cousins PEA (palmitoylethanolamide) and OEA (oleoylethanolamide).
• Choose a label that lists every amount, uses third-party tested ingredients and contains no CBD or THC if that matters to you.
• Compare price per serving, not price per bottle.
• In human studies, 45 minutes of moderate running raised blood anandamide in a trial of 63 adults (Siebers et al., 2021), and 350 mg of PEA a day was studied for 8 weeks in 103 adults (Rao et al., 2021).

What Is an Anandamide Supplement?

Anandamide (also called AEA) is one of the signaling molecules of the endocannabinoid system, the network of messengers, receptors and enzymes that helps keep mood, motivation and a sense of balance steady. Researchers first isolated it from brain tissue in 1992 and showed that it binds the same cannabinoid receptor that plant cannabinoids act on, which is why it is called an endocannabinoid: a cannabinoid made inside the body (Devane et al., 1992). Our anandamide ingredient page covers the molecule itself.

Your body makes anandamide when it needs it and then clears it. The enzyme that breaks it down is called FAAH (fatty acid amide hydrolase), first described in 1996 as an enzyme that breaks down anandamide and related fatty acid amides (Cravatt et al., 1996). An anandamide supplement is a capsule built around anandamide, usually with related compounds that share this system. For how anandamide connects to mood day to day, see anandamide supplements for mood.

Types of Anandamide Supplements

Products sold for anandamide support fall into a few groups, and many combine more than one.

Type	What it is
Anandamide itself	The endocannabinoid your body makes, supplied directly in a capsule
PEA (palmitoylethanolamide)	A related fatty acid amide your body also makes; sold alone or as a partner to anandamide
OEA (oleoylethanolamide)	Another close cousin, which works mainly through a different receptor called PPAR-alpha
FAAH-related plant compounds	Plant flavonoids such as kaempferol, studied in the lab for how they interact with FAAH
Kanna-type products	A South African plant sold for mood; not an endocannabinoid, so it sits outside this system

Kaempferol research so far is early: in a 2020 study it slowed FAAH in a lab test and changed fear-learning behavior in rats (Molecules, 2020). If kanna is what you are weighing, our guide to the best kanna supplement covers it, and our Kanna Nasal Spray pairs kanna extract with L-theanine in alkaline water, in three strengths. If your goal is fullness and focus rather than mood, our OEA Supplement is built around 200 mg of OEA per serving with PEA, L-theanine, acetyl-L-carnitine and green tea extract.

What Research Measured: Anandamide, PEA and OEA

Anandamide

Most human research on anandamide measures the anandamide your body makes. In a randomized, placebo-controlled study of 63 adults, 45 minutes of moderate treadmill running raised blood levels of anandamide, and people reported feeling more euphoric and less anxious than after walking (Siebers et al., 2021). Our guide on how to increase anandamide covers exercise, food and daily habits.

PEA

PEA is an endogenous fatty acid amide, meaning your body makes it, much like anandamide (Basu, 2025). In an 8-week double-blind trial, 103 adults with self-reported poor sleep took 350 mg of PEA or a placebo an hour before bed. Among those who took more than 10 minutes to fall asleep, the PEA group fell asleep sooner at weeks 4 and 8, and the PEA group felt fully awake sooner in the morning at week 8. Overall sleep quality scores improved in both groups alike (Rao et al., 2021). In lab studies using rat brain tissue and cells, PEA and OEA reduced how quickly anandamide was broken down, which is the main reason they are paired with it (Jonsson et al., 2001). Our PEA guide goes deeper.

OEA

OEA is best known from animal research. In mice, it bound a receptor called PPAR-alpha and increased fullness after eating, and this effect disappeared in mice bred without that receptor (Fu et al., 2003). See our guide to OEA supplements for more.

L-theanine, a common partner

Many anandamide formulas add L-theanine for calm. In a 4-week crossover trial, 30 healthy adults (21 of them women) took 200 mg of L-theanine a day; scores for stress-related feelings and sleep quality improved, and so did verbal fluency (Hidese et al., 2019).

How to Choose the Best Anandamide Supplement

Use this checklist when you compare anandamide pills side by side:

Check	What to look for
1. Every amount on the label	Milligrams listed for anandamide and each partner ingredient, not one total for a blend
2. No proprietary blend	A blend can hide how much of each ingredient you actually get
3. Third-party tested ingredients	Ingredients checked by an outside lab, stated on the label or website
4. No CBD or THC	Anandamide is made by your body, so a formula does not need cannabis compounds
5. Serving size	How many capsules make one serving, and how many servings are in the bottle
6. Price per serving	Divide the price by the number of servings to compare fairly

Partner ingredients matter too: a formula with anandamide, PEA and OEA covers the main members of this family in one capsule.

Red Flags to Avoid

• A label that gives one total for a blend instead of the amount of each ingredient.
• Promises of instant bliss or effects that last forever. A good formula supports your own system rather than overriding it.
• No word on ingredient testing anywhere on the label or website.
• CBD or THC slipped into the ingredient list when you were not looking for them.
• A low bottle price that hides a small serving count, which makes the price per serving higher than it looks.

Anandamide Supplement Side Effects and Safety

Most people tolerate these ingredients well. Your body already makes anandamide, PEA and OEA. In the 8-week PEA trial, 2 people on PEA and 4 on placebo stopped because of side effects, and the researchers found no difference in tolerability between the groups (Rao et al., 2021). Talk with your clinician before you start if you are pregnant or breastfeeding or take prescription medicine.

Where Our Anandamide Supplement Fits

Our Anandamide Supplement was made to pass the checklist above. Every 2-capsule serving gives:

Ingredient	Per 2 capsules
Anandamide	600 mg
Palmitoylethanolamide (PEA)	150 mg
Oleoylethanolamide (OEA)	100 mg
L-theanine	100 mg

The other ingredients are ginger extract and vegan capsules. There is no CBD or THC, and it is made with third-party tested ingredients. Take 2 capsules daily in the morning, with or without food. Each bottle holds 30 servings for $59, about $1.97 a serving. Subscribe and save 15 percent and it is $50.15, about $1.67 a serving, or choose the 3-month subscription at $117.99, which works out to $39.33 a bottle, about $1.31 a serving. It is designed to support a steady mood, calm and motivation.

Benefits build with consistent daily use. Months 1 to 2 can bring early changes, and 3 months and beyond is where the full benefit builds. For other options that support a calm, steady mood, see our guide to the best supplements for stress and mood and our stress, mood and nervous system guide.

Frequently Asked Questions

What is the best anandamide supplement?

The best one lists the amount of anandamide and every partner ingredient, has no proprietary blend, uses third-party tested ingredients and has a fair price per serving. Ours gives 600 mg of anandamide with 150 mg of PEA, 100 mg of OEA and 100 mg of L-theanine per 2 capsules.

Do anandamide supplements work?

Human research has measured the anandamide your body makes, which rose in adults after 45 minutes of running, and has tested partners such as PEA and L-theanine in controlled trials. Anandamide supplements are designed to support that same system for a steady mood, calm and motivation.

Where can I buy anandamide?

Anandamide is sold as a capsule supplement, usually combined with PEA and OEA. You can buy our Anandamide Supplement directly from our store.

Do anandamide pills contain CBD or THC?

Not necessarily. Anandamide is made by your body, so a formula does not need cannabis compounds. Ours contains no CBD or THC; check the label of any product you compare.

What are the side effects of anandamide supplements?

Most people tolerate them well. In an 8-week trial of PEA, side effects were no more common than with placebo. Talk with your clinician first if you are pregnant, breastfeeding or take prescription medicine.

How do I choose an anandamide supplement?

Check that every amount is on the label, that there is no proprietary blend, that the ingredients are third-party tested, whether it has CBD or THC, the serving size and the price per serving.

What is the difference between anandamide, PEA and OEA?

All three are fatty acid amides your body makes. Anandamide binds the cannabinoid receptor, PEA is a close cousin often paired with it, and OEA works mainly through a receptor called PPAR-alpha.

When should I take an anandamide supplement?

Follow the label. Ours is taken as 2 capsules daily in the morning, with or without food.

Sources

• Devane WA, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science, 1992. https://pubmed.ncbi.nlm.nih.gov/1470919/
• Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature, 1996. https://www.nature.com/articles/384083a0
• Siebers M, et al. Exercise-induced euphoria and anxiolysis do not depend on endogenous opioids in humans. Psychoneuroendocrinology, 2021. https://pubmed.ncbi.nlm.nih.gov/33582575/
• Rao A, Ebelt P, Mallard A, et al. Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study. Sleep Science and Practice, 2021. https://sleep.biomedcentral.com/articles/10.1186/s41606-021-00065-3
• Jonsson KO, Vandevoorde S, Lambert DM, Tiger G, Fowler CJ. Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. British Journal of Pharmacology, 2001. https://www.farm.ucl.ac.be/Abstracts-FARM/Jonsson-2001-1.htm
• Fu J, Gaetani S, Oveisi F, et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature, 2003. https://www.nature.com/articles/nature01921
• Hidese S, Ogawa S, Ota M, et al. Effects of L-theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. Nutrients, 2019. https://pubmed.ncbi.nlm.nih.gov/31623400/
• Basu D. Palmitoylethanolamide, an endogenous fatty acid amide, and its pleiotropic health benefits: a narrative review. Journal of Biomedical Research, 2025. https://journal.hep.com.cn/jbr/EN/10.7555/JBR.38.20240053
• Kaempferol facilitated extinction learning in contextual fear conditioned rats via inhibition of fatty-acid amide hydrolase. Molecules, 2020. https://doaj.org/article/7fded2b6d39243a49b1c5f0a2327161f

These statements have not been evaluated by the Food and Drug Administration. This content is for education and is not medical advice. Our products are not intended to diagnose, treat, cure or prevent any disease. Talk with a healthcare provider before starting a new supplement if you are pregnant, breastfeeding or taking medication.