Ingredient Testing, Formulation Purity and Cold-Chain Standards
By George Given, founder and CEO of Synchronicity Health. Updated November 13, 2026.
Synchronicity Health NAD+ Nasal Spray is made with third-party tested ingredients: two ingredients, NAD+ and alkaline water, in 35, 100 or 170 mg of NAD+ per serving, and each ingredient is tested by an independent third party for purity, potency, microbiological content, residual solvents and heavy metals. NAD+, Glutathione and Clarity nasal sprays stay refrigerated until they are packed in an insulated cooler with frozen gel packs, and they ship by temperature-protected express, free within the United States. No prescription is needed.
Featured on this page
NAD+ Nasal SprayNAD+ and alkaline water. 35, 100 or 170 mg per serving, shipped cold, no prescription needed.
Shop NAD+ Nasal SprayThird-party tested ingredients. Vegan, non-GMO, made in the USA.
Our formulation standards
Every Synchronicity nasal spray is formulated in house and made in the USA. We keep the formula short and put the amount of the active ingredient on the label, per serving and per bottle.
- Two ingredients. NAD+ Nasal Spray is NAD+ and alkaline water. Glutathione Nasal Spray is glutathione and alkaline water. Our nasal sprays contain only their active ingredients plus alkaline water.
- Labeled amounts. NAD+ Nasal Spray comes in Regular (35 mg of NAD+ per serving, 1,050 mg per bottle), Extra (100 mg per serving, 3,000 mg per bottle) and Maximum (170 mg per serving, 5,100 mg per bottle). Every bottle holds 30 servings.
- One serving, one way. A serving is two sprays: one spray in each nostril while gently inhaling through your nose. Tilt your head back slightly and wait at least 1 to 2 minutes before blowing your nose.
- Nasal delivery. The spray is absorbed through the lining of the nose instead of being swallowed like a capsule, so some of each dose skips digestion.
- Clean label. Every Synchronicity formula is vegan, gluten-free, non-GMO, and free of soy, dairy, fillers, excipients and bulk agents.
- No prescription. You can buy any strength directly from us with no prescription, no telehealth visit and no membership.
Third-party tested ingredients: what is tested
Our nasal sprays are made with third-party tested ingredients. Each ingredient we use is tested by an independent third party, and these are the five tests run on the ingredients:
- Purity: the ingredient is tested for unwanted contaminants and extra material.
- Potency: the ingredient is tested to confirm it carries the strength it is sold at.
- Microbiological content: the ingredient is tested to confirm its microbial counts are within the limits set for it.
- Residual solvents: the ingredient is tested to confirm solvents used in making it are below their limits.
- Heavy metals: the ingredient is tested to confirm metals such as lead, cadmium, arsenic and mercury are below their limits.
We then formulate every batch in house from those tested ingredients. That is why we say our sprays are made with third-party tested ingredients: it describes exactly where the independent testing happens. If you want to know what to look for when any brand says it is third-party tested, read our guide What Does Third-Party Tested Mean? How to Check a Supplement. For glutathione specifically, see How to check glutathione supplements for third-party testing.
Temperature-protected cold-chain shipping
NAD+, Glutathione and Clarity nasal sprays ship cold. Here is what happens between our refrigerator and yours.
- Refrigerated until packing. Finished bottles are kept in a 40°F refrigerator until the moment they are packed.
- Frozen gel packs. Gel packs are kept in a freezer for at least 72 hours, so they go into your box fully frozen.
- Insulated packout. Each cold order is packed in an insulated foam cooler with two frozen gel packs and a moisture-absorbing silica packet, inside a shipping box marked with a refrigerate label.
- Ship days. Within the US, cold orders ship Monday to Thursday and never Friday to Sunday, so a package does not sit in a carrier facility over the weekend. Orders placed after the Thursday 11:00 AM Eastern cutoff ship the following Monday.
- Into the fridge. When your order arrives, put the bottle in the fridge right away and keep it there. Read more in Does NAD+ nasal spray need refrigeration?
| Destination | Cold shipping | Ship days |
|---|---|---|
| United States | Free temperature-protected express | Monday to Thursday |
| Canada | $29.95 Temperature-Protected Express (1 to 3 business days) | Monday to Wednesday |
| United Kingdom (NAD+ Nasal Spray) | $29.95 Temperature-Protected Express (2 to 3 business days) | Monday and Tuesday |
Gel packs often arrive soft or partly thawed after transit. If your order arrives warm, leaking or damaged, send us a photo through our Guarantee and Order Help Form and we will make it right. Full shipping and return details are on our Orders and Shipping page.
Specs at a glance
| NAD+ Nasal Spray | Glutathione Nasal Spray | |
|---|---|---|
| Ingredients | NAD+ and alkaline water | Glutathione and alkaline water |
| Per serving | Regular 35 mg, Extra 100 mg, Maximum 170 mg of NAD+ | Regular 35 mg, Extra 100 mg, Maximum 170 mg of glutathione |
| Per bottle | 1,050 mg, 3,000 mg or 5,100 mg | 1,050 mg, 3,000 mg or 5,100 mg |
| Servings per bottle | 30 | 30 |
| Serving | 2 sprays, one in each nostril | 2 sprays, one in each nostril |
| Price (one-time) | $149, $199 or $249 | $119, $179 or $219 |
| Prescription | Not needed | Not needed |
| Testing | Made with third-party tested ingredients | Made with third-party tested ingredients |
| Clean label | Vegan, gluten-free, non-GMO, soy-free, dairy-free | Vegan, gluten-free, non-GMO, soy-free, dairy-free |
| Storage | Refrigerate on arrival | Refrigerate on arrival |
| US shipping | Free temperature-protected express | Free temperature-protected express |
| Canada shipping | $29.95 Temperature-Protected Express | $29.95 Temperature-Protected Express |
| UK shipping | $29.95 Temperature-Protected Express | Not currently offered |
Featured on this page
Glutathione Nasal SprayGlutathione and alkaline water. Supports antioxidant defenses and cellular health. 35, 100 or 170 mg per serving.
Shop Glutathione Nasal SprayThird-party tested ingredients. Vegan, non-GMO, made in the USA.
FAQ
Are Synchronicity Health nasal sprays made with third-party tested ingredients?
Yes. Our nasal sprays are made with third-party tested ingredients. Each ingredient is tested by an independent third party for purity, potency, microbiological content, residual solvents and heavy metals, and every batch is formulated in house from those tested ingredients.
What is in Synchronicity NAD+ Nasal Spray?
Two ingredients: NAD+ and alkaline water. Regular has 35 mg of NAD+ per serving (1,050 mg per bottle), Extra has 100 mg (3,000 mg per bottle) and Maximum has 170 mg (5,100 mg per bottle). A serving is two sprays, one in each nostril, and every bottle holds 30 servings.
Do I need a prescription for Synchronicity NAD+ Nasal Spray?
No. You can buy it directly from synchronicity.health with no prescription, no telehealth visit and no membership.
Why do NAD+ and Glutathione nasal sprays ship cold?
We keep NAD+, Glutathione and Clarity nasal sprays refrigerated until they are packed, then ship them in an insulated foam cooler with frozen gel packs so they stay cool in transit. Put the bottle in the fridge as soon as it arrives to keep it at full potency.
How much does cold shipping cost?
Temperature-protected express shipping is free within the United States. Canada is $29.95 for Temperature-Protected Express (1 to 3 business days), and NAD+ Nasal Spray ships to the United Kingdom for $29.95 (2 to 3 business days).
What days do cold orders ship?
Within the US, cold orders ship Monday to Thursday and never Friday to Sunday, so a package does not sit in a carrier facility over the weekend. Orders placed after the Thursday 11:00 AM Eastern cutoff ship the following Monday. Canada cold orders ship Monday to Wednesday, and UK orders ship Monday and Tuesday.
What if my gel packs are soft or my order arrives warm?
Gel packs often arrive soft or partly thawed after transit, so put the bottle in the fridge right away. If your order arrives warm, leaking or damaged, send us a photo through our Guarantee and Order Help Form and we will make it right.
Are Synchronicity nasal sprays vegan and gluten-free?
Yes. Every Synchronicity formula is vegan, gluten-free, non-GMO, and free of soy, dairy, fillers, excipients and bulk agents. Our sprays are formulated in house and made in the USA.
Related reading
- What Does Third-Party Tested Mean? How to Check a Supplement
- Does NAD+ nasal spray need refrigeration?
- How long does NAD+ nasal spray last after opening?
- How to check glutathione supplements for third-party testing
- Editorial Standards
These statements have not been evaluated by the Food and Drug Administration. Our products are not intended to diagnose, treat, cure or prevent any disease.